Catalytic promiscuity and the divergent evolution of DNA repair enzymes

被引：106

作者：

O'Brien, PJ ^{[1
]}

机构：

[1] Univ Michigan, Dept Biol Chem, Ann Arbor, MI 48109 USA

来源：

CHEMICAL REVIEWS | 2006年 / 106卷 / 02期

关键词：

D O I：

10.1021/cr040481v

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This review discusses the known evolutionary relationships among DNA repair enzymes and between DNA repair enzymes and other cellular enzymes, focusing on the divergence of enzymatic function. Discussions include: overview of catalytic promiscuity and the evolutionary diversification of enzymes; chemical landscape for DNA damage and repair; overview of DNA repair pathways; examples of DNA repair enzymes that exhibit catalytic promiscuity; mechanistically diverse DNA repair enzyme superfamilies; and changes in substrate and reaction specificity of DNA repair enzymes.

引用

页码：720 / 752

页数：33

共 332 条

[31] Catalytic promiscuity in biocatalysis: Using old enzymes to form new bonds and follow new pathways [J].

Bornscheuer, UT ;

Kazlauskas, RJ .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2004, 43 (45) :6032-6040

[32] DNA repair excision nuclease attacks undamaged DNA - A potential source of spontaneous mutations [J].

Branum, ME ;

Reardon, JT ;

Sancar, A .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (27) :25421-25426

[33] Conversion of bovine pancreatic DNase I to a repair endonuclease with a high selectivity for abasic sites [J].

Cal, S ;

Tan, KL ;

McGregor, A ;

Connolly, BA .

EMBO JOURNAL, 1998, 17 (23) :7128-7138

[34] Metallo-β-lactamase fold within nucleic acids processing enzymes:: the β-CASP family [J].

Callebaut, I ;

Moshous, D ;

Mornon, JP ;

de Villartay, JP .

NUCLEIC ACIDS RESEARCH, 2002, 30 (16) :3592-3601

[35] X-RAY-ANALYSIS OF D-XYLOSE ISOMERASE AT 1.9 A - NATIVE ENZYME IN COMPLEX WITH SUBSTRATE AND WITH A MECHANISM-DESIGNED INACTIVATOR [J].

CARRELL, HL ;

GLUSKER, JP ;

BURGER, V ;

MANFRE, F ;

TRITSCH, D ;

BIELLMANN, JF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (12) :4440-4444

[36] Understanding the transition states of phosphodiester bond cleavage: Insights from heavy atom isotope effects [J].

Cassano, AG ;

Anderson, VE ;

Harris, ME .

BIOPOLYMERS, 2004, 73 (01) :110-129

[37] Structural basis for FEN-1 substrate specificity and PCNA-mediated activation in DNA replication and repair [J].

Chapados, BR ;

Hosfield, DJ ;

Han, S ;

Qiu, JZ ;

Yelent, B ;

Shen, BH ;

Tainer, JA .

CELL, 2004, 116 (01) :39-50

[38] Recognition of the nonpolar base 4-methylindole in DNA by the DNA repair adenine glycosylase MutY [J].

Chepanoske, CL ;

Langelier, CR ;

Chmiel, NH ;

David, SS .

ORGANIC LETTERS, 2000, 2 (09) :1341-1344

[39] An exonucleolytic activity of human apurinic/apyrimidinic endonuclease on 3′ mispaired DNA [J].

Chou, KM ;

Cheng, YC .

NATURE, 2002, 415 (6872) :655-659

[40] Functional bias and spatial organization of genes in mutational hot and cold regions in the human genome [J].

Chuang, JH ;

Li, H .

PLOS BIOLOGY, 2004, 2 (02) :253-263

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