Catalytic promiscuity and the divergent evolution of DNA repair enzymes

被引：106

作者：

O'Brien, PJ ^{[1
]}

机构：

[1] Univ Michigan, Dept Biol Chem, Ann Arbor, MI 48109 USA

来源：

CHEMICAL REVIEWS | 2006年 / 106卷 / 02期

关键词：

D O I：

10.1021/cr040481v

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This review discusses the known evolutionary relationships among DNA repair enzymes and between DNA repair enzymes and other cellular enzymes, focusing on the divergence of enzymatic function. Discussions include: overview of catalytic promiscuity and the evolutionary diversification of enzymes; chemical landscape for DNA damage and repair; overview of DNA repair pathways; examples of DNA repair enzymes that exhibit catalytic promiscuity; mechanistically diverse DNA repair enzyme superfamilies; and changes in substrate and reaction specificity of DNA repair enzymes.

引用

页码：720 / 752

页数：33

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