Synthesis of a new inhibitor of alpha-fucosidase

被引：35

作者：

Igarashi, Y ^{[1
]}

Ichikawa, M ^{[1
]}

Ichikawa, Y ^{[1
]}

机构：

[1] JOHNS HOPKINS UNIV,SCH MED,DEPT PHARMACOL & MOLEC SCI,BALTIMORE,MD 21205

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 05期

关键词：

D O I：

10.1016/0960-894X(96)00068-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new fucose-type iminosugar in which the nitrogen is placed in the anomeric position was synthesized from D-ribose and was shown to be a potent inhibitor of alpha-fucosidase (Ki = 8.4 mu M).

引用

页码：553 / 558

页数：6

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