Formation and dissolution of hen egg white lysozyme amyloid fibrils in protic ionic liquids

被引：94

作者：

Byrne, Nolene ^{[1
]}

Angell, C. Austen ^{[1
]}

机构：

[1] Arizona State Univ, Dept Chem & Biochem, Tempe, AZ 85287 USA

来源：

CHEMICAL COMMUNICATIONS | 2009年 / 09期

关键词：

PROTEIN; AGGREGATION; DISEASE;

D O I：

10.1039/b817590j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The formation of amyloid fibrils from non-disease-related proteins demonstrates that any protein can adopt this "rogue'' form; we show that it is possible to use protic ionic liquids to fibrilize hen egg white lysozyme, and then subsequently to dissolve the fibrils with up to 72% restoration of enzymatic activity.

引用

页码：1046 / 1048

页数：3

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