Regioselective, Solvent-Free Synthesis of 3-Aminoimidazo[1,2-a]pyrimidines Under Microwave Irradiation Promoted by Zeolite HY

被引：19

作者：

Thompson, Mark J. ^{[1
]}

Hurst, Jenny M. ^{[1
]}

Chen, Beining ^{[1
]}

机构：

[1] Univ Sheffield, Dept Chem, Sheffield S3 7HF, S Yorkshire, England

来源：

SYNLETT | 2008年 / 20期

基金：

英国生物技术与生命科学研究理事会;

关键词：

multicomponent reactions; heterocycles; zeolites; regioselectivity; bicyclic compounds;

D O I：

10.1055/s-0028-1087274

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Microwave-assisted, solvent-free condensation of 2-aminopyrimidine with aldehydes and isonitriles gave the desired 3-aminoimidazo[1,2-a]pyrimidine products with good to excellent regioselectivity. A hydrogen zeolite ('zeolite HY') was found to be a novel and effective promoter for the reaction, generally leading to clean conversion and also permitting use of the normally unreactive 4,6-dimethyl-2-aminopyrimidine.

引用

页码：3183 / 3187

页数：5

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