Molybdenum trioxide catalyzed oxidative cross-dehydrogenative coupling of benzylic sp3 C-H bonds: synthesis of α-aminophosphonates under aerobic conditions

被引：46

作者：

Alagiri, Kaliyamoorthy ^{[1
]}

Devadig, Pradeep ^{[1
]}

Prabhu, Kandikere R. ^{[1
]}

机构：

[1] Indian Inst Sci, Dept Organ Chem, Bangalore 560012, Karnataka, India

来源：

TETRAHEDRON LETTERS | 2012年 / 53卷 / 12期

关键词：

CDC reaction; Aerobic oxidation; C-H functionalization; Molybdenum; Hydrophosphorylation; TERTIARY-AMINES; MOLECULAR-OXYGEN; HYDROGEN-PEROXIDE; CYANATION; TETRAHYDROISOQUINOLINES; FUNCTIONALIZATIONS; ACTIVATION; INDOLATION; VANADIUM; KETONES;

D O I：

10.1016/j.tetlet.2012.01.031

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Molybdenum trioxide (MoO3) catalyzed efficient oxidative cross-dehydrogenative-coupling (CDC) method for C-H functionalization of N-aryl tetrahydroisoquinolines has been explored. This user-friendly method of synthesizing alpha-aminophosphonates employs 1.1 equiv of dialkyl-H-phosphonate under aerobic condition. Formation of new C-P bonds from unfunctionalized starting materials under environmentally benign conditions provides an excellent avenue for the synthesis of biologically active alpha-aminophosphonates. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：1456 / 1459

页数：4

共 49 条

[11] Visible-Light Photoredox Catalysis: Aza-Henry Reactions via C-H Functionalization [J].