Hypoxia inducible factor-1α: Its role in colorectal carcinogenesis and metastasis

被引：166

作者：

Nagaraju, Ganji Purnachandra ^{[1
]}

Bramhachari, Pallaval Veera ^{[2
]}

Raghu, Godi ^{[2
]}

El-Rayes, Bassel F. ^{[1
]}

机构：

[1] Emory Univ, Dept Hematol & Med Oncol, Winship Canc Inst, Atlanta, GA 30322 USA

[2] Krishna Univ, Dept Biotechnol, Machilipatnam 521001, AP, India

来源：

CANCER LETTERS | 2015年 / 366卷 / 01期

关键词：

HIF1; alpha; Metastasis; Stemness; Tumor resistance; Colorectal cancer; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; MITOCHONDRIAL COMPLEX-III; HEMATOPOIETIC STEM-CELLS; FREE-RADICAL GENERATION; MULTIDRUG-RESISTANCE; DOWN-REGULATION; FACTOR; 1-ALPHA; UP-REGULATION; CANCER CELLS; HIF-ALPHA;

D O I：

10.1016/j.canlet.2015.06.005

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Tumor growth creates a hypoxic microenvironment, which promotes angiogenesis and aggressive tumor growth and invasion. HIF1 alpha is a central molecule involved in mediating these effects of hypoxia. In colorectal cancer (CRC), hypoxia stabilizes the transcription factor HIF1 alpha, leading to the expression of genes that are involved in tumor vascularization, metastasis/migration, cell survival and chemo-resistance. Therefore, HIF1 alpha is a rational target for the development of new therapeutics for CRC. This article reviews the central role of HIF1 alpha in CRC angiogenesis, metastasis, and progression as well as the strategies to target HIF1 alpha stabilization. (C) 2015 Elsevier Ireland Ltd. All rights reserved.

引用

页码：11 / 18

页数：8

共 142 条

[1]

Molecular targets of aspirin and cancer prevention [J].

Alfonso, L. ;

Ai, G. ;

Spitale, R. C. ;

Bhat, G. J. .

BRITISH JOURNAL OF CANCER, 2014, 111 (01) :61-67

[2]

The functions of animal microRNAs [J].

Ambros, V .

NATURE, 2004, 431 (7006) :350-355

[3]

[Anonymous], MOL CARCINOG

[4]

[Anonymous], SURG CURR RES

[5]

Nonsteroidal anti-inflammatory drugs and prevention of colorectal cancer. [J].

Arber N. ;

DuBois R.N. .

Current Gastroenterology Reports, 1999, 1 (5) :441-448

[6]

Asano TK, 2004, COCHRANE DB SYST REV

[7]

The significance of cancer cell expression of the chemokine receptor CXCR4 [J].

Balkwill, F .

SEMINARS IN CANCER BIOLOGY, 2004, 14 (03) :171-179

[8]

Overexpression of stromal cell-derived factor 1 and its receptor CXCR4 induces autocrine/paracrine cell proliferation in human pituitary adenomas [J].

Barbieri, Federica ;

Bajetto, Adriana ;

Stumm, Ralf ;

Pattarozzi, Alessandra ;

Porcile, Carola ;

Zona, Gianluigi ;

Dorcaratto, Alessandra ;

Ravetti, Jean-Louis ;

Minuto, Francesco ;

Spaziante, Renato ;

Schettini, Gennaro ;

Ferone, Diego ;

Florio, Tullio .

CLINICAL CANCER RESEARCH, 2008, 14 (16) :5022-5032

[9]

MicroRNAs: Target Recognition and Regulatory Functions [J].

Bartel, David P. .

CELL, 2009, 136 (02) :215-233

[10]

MicroRNAs: Genomics, biogenesis, mechanism, and function (Reprinted from Cell, vol 116, pg 281-297, 2004) [J].

Bartel, David P. .

CELL, 2007, 131 (04) :11-29

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