Synthesis of the enantiopure C15-C26 segment of phorboxazole A and B

被引:50
作者
Wolbers, P [1 ]
Misske, AM [1 ]
Hoffmann, HMR [1 ]
机构
[1] Univ Hannover, Inst Organ Chem, D-30167 Hannover, Germany
关键词
marine macrolides; oxazole synthesis; stereocontrol; HWE olefination;
D O I
10.1016/S0040-4039(99)00803-5
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Two approaches towards an enantiopure C15-C26 segment of the phorboxazoles starting from the corresponding C20-C26 aldehyde are presented. A variety of functionalized oxazoles have been synthesized via the rhodium(II) acetate catalyzed cycloaddition of dimethyl diazomalonate to substituted nitriles. (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:4527 / 4530
页数:4
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