Effect of Antiretroviral Therapy on HIV Reservoirs in Elite Controllers

被引：54

作者：

Chun, Tae-Wook ^{[1
]}

Justement, J. Shawn ^{[1
]}

Murray, Danielle ^{[1
]}

Kim, Connie J. ^{[2
]}

Blazkova, Jana ^{[1
]}

Hallahan, Claire W. ^{[1
]}

Benko, Erika ^{[3
]}

Costiniuk, Cecilia T. ^{[4
]}

Kandel, Gabor ^{[5
,6
]}

Ostrowski, Mario ^{[2
,5
,6
]}

Kaul, Rupert ^{[2
]}

Moir, Susan ^{[1
]}

Casazza, Joseph P. ^{[1
]}

Koup, Richard A. ^{[1
]}

Kovacs, Colin ^{[2
,3
]}

Fauci, Anthony S. ^{[1
]}

机构：

[1] NIAID, NIH, Bethesda, MD 20892 USA

[2] Univ Toronto, Dept Med, Toronto, ON, Canada

[3] Maple Leaf Med Clin, Toronto, ON, Canada

[4] Ottawa Hosp, Dept Med, Toronto, ON, Canada

[5] St Michaels Hosp, Toronto, ON M5B 1W8, Canada

[6] Li Ka Shing Knowledge Inst, Toronto, ON, Canada

来源：

JOURNAL OF INFECTIOUS DISEASES | 2013年 / 208卷 / 09期

基金：

美国国家卫生研究院;

关键词：

human immunodeficiency virus; viral reservoirs; antiretroviral therapy; elite controllers; LOW-LEVEL VIREMIA; VIRUS; INTENSIFICATION; INDIVIDUALS; REPLICATION; SUPPRESSORS; INFECTION;

D O I：

10.1093/infdis/jit306

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Elite controllers suppress human immunodeficiency virus (HIV) viremia to below the limit of detection in the absence of antiretroviral therapy (ART). However, precise frequencies of CD4(+) T cells carrying replication-competent HIV and/or the dynamics of the infectious viral reservoirs in response to initiation and discontinuation of ART in elite controllers are unknown. We show that the size of the pool of CD4(+) T cells harboring infectious HIV diminished significantly after initiation of ART and rebounded to baseline upon cessation of therapy. Our data provide compelling evidence that persistent viral replication occurs in untreated elite controllers even in the absence of detectable plasma viremia.

引用

收藏

页码：1443 / 1447

页数：5

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