Self-indicating amine scavenger resins

被引：16

作者：

Cho, JK

White, PD

Klute, W

Dean, TW

Bradley, M ^{[1
]}

机构：

[1] Univ Southampton, Sch Chem, Combinatorial Ctr Excellence, Southampton SO17 1BJ, Hants, England

[2] Merck Biosci Inc, Nottingham NG9 2JR, England

[3] Pfizer Global Res & Dev, Sandwich CT13 9NJ, Kent, England

[4] GlaxoSmithKline, Discovery Res, Stevenage SG1 2NY, Herts, England

来源：

CHEMICAL COMMUNICATIONS | 2004年 / 05期

关键词：

D O I：

10.1039/b315426b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Self-indicating methylisocyanate resin, which functions as both a scavenger and an indicator for amines, was used for in-situ reaction monitoring and purification of a urea based library.

引用

页码：502 / 503

页数：2

共 15 条

[1] Generalized dipeptidomimetic template: Solution phase parallel synthesis of combinatorial libraries [J].

Boger, DL ;

Tarby, CM ;

Myers, PL ;

Caporale, LH .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1996, 118 (08) :2109-2110

[2] Solid-supported reagent strategies for rapid purification of combinatorial synthesis products [J].

Booth, RJ ;

Hodges, JC .

ACCOUNTS OF CHEMICAL RESEARCH, 1999, 32 (01) :18-26

[3] Polymer-supported quenching reagents for parallel purification [J].

Booth, RJ ;

Hodges, JC .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1997, 119 (21) :4882-4886

[4]

CARRELL T, 1994, ANGEW CHEM INT EDIT, V33, P2059

[5] Self-indicating resins: Sensor beads and in situ reaction monitoring [J].

Cho, JK ;

White, PD ;

Klute, W ;

Dean, TW ;

Bradley, M .

JOURNAL OF COMBINATORIAL CHEMISTRY, 2003, 5 (05) :632-636

[6] Combinatorial synthesis of dihydropyridone libraries and their derivatives [J].

Creswell, MW ;

Bolton, GL ;

Hodges, JC ;

Meppen, M .

TETRAHEDRON, 1998, 54 (16) :3983-3998

[7] Stille couplings with fluorous tin reactants: Attractive features for preparative organic synthesis and liquid-phase combinatorial synthesis [J].

Curran, DP ;

Hoshino, M .

JOURNAL OF ORGANIC CHEMISTRY, 1996, 61 (19) :6480-6481

[8] Solid phase synthesis of urea libraries using a diversifiable thiophenoxy carbonyl linker [J].

Dressman, BA ;

Singh, U ;

Kaldor, SW .

TETRAHEDRON LETTERS, 1998, 39 (22) :3631-3634

[9]

Eames J, 2001, EUR J ORG CHEM, V2001, P1213

[10] Remarkable three-step-one-pot solution phase preparation of novel imidazolines utilizing a UDC (Ugi/de-Boc/cyclize) strategy [J].

Hulme, C ;

Ma, L ;

Romano, J ;

Morrissette, M .

TETRAHEDRON LETTERS, 1999, 40 (45) :7925-7928

← 1 2 →