(IPr)Pd(acac)Cl: An easily synthesized, efficient, and versatile precatalyst for C-N and C-C bond formation

被引：165

作者：

Marion, N

Ecarnot, EC

Navarro, O

Amoroso, D

Bell, A

Nolan, SP ^{[1
]}

机构：

[1] Univ New Orleans, Dept Chem, Dept Chem, New Orleans, LA 70148 USA

[2] Promerus LLC, Brecksville, OH 44141 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2006年 / 71卷 / 10期

关键词：

D O I：

10.1021/jo060190h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A very straightforward synthesis of (IPr) Pd(acac)Cl from two commercially available starting materials, Pd(acac)(2) and IPr center dot HCl [acac = acetylacetonate; IPr = N,N'-bis(2,6-diisopropylphenyl)imidazol-2-ylidene], has been developed. The resulting complex, ( IPr) Pd( acac) Cl ( 1), has proven to be a highly active Pd-II precatalyst in the Buchwald-Hartwig and the alpha-ketone arylation reactions. A wide range of substrates has been screened, including unactivated, sterically hindered, and heterocyclic aryl chlorides.

引用

页码：3816 / 3821

页数：6

共 43 条

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