Spirocyclic nonpeptide glycoprotein IIb-IIIa antagonists. Part 3: Synthesis and SAR of potent and specific 2,8-diazaspiro[4.5]decanes

被引：15

作者：

Mehrotra, MM

Heath, JA

Rose, JW

Smyth, MS

Seroogy, J

Volkots, DL

Ruhter, G

Schotten, T

Alaimo, L

Park, G

Pandey, A

Scarborough, RM ^{[1
]}

机构：

[1] COR Therapeut Inc, Dept Med Chem, San Francisco, CA 94080 USA

[2] COR Therapeut Inc, Dept Biol, San Francisco, CA 94080 USA

[3] Lilly Res Labs, Hamburg, Germany

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 07期

关键词：

D O I：

10.1016/S0960-894X(02)00095-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis and biological activity of analogues containing spiro piperidinylpyridine and pyrrolidinylpyridine templates are described. The potent activity of these compounds as platelet aggregation inhibitors demonstrates the utility of the spiro structures as central template for nonpeptide RGD mimics. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：1103 / 1107

页数：5

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