Microwave-assisted deuterium exchange reactions for the preparation of reactive intermediates

被引：33

作者：

Fodor-Csorba, K

Galli, G

Holly, S

Gäcs-Baitz, E

机构：

[1] Hungarian Acad Sci, Res Inst Solid State Phys & Opt, H-1525 Budapest, Hungary

[2] Univ Pisa, Dipartimento Chim & Chim Ind, I-56126 Pisa, Italy

[3] Hungarian Acad Sci, Chem Res Ctr, Inst Chem, H-1525 Budapest, Hungary

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 21期

关键词：

D O I：

10.1016/S0040-4039(02)00706-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Deuterium labelling of a number of ketones was achieved on a preparative scale by a microwave-assisted deuterium exchange reaction with D2O CF3COOD. The reaction was rapid (<15 min) and highly isotope-efficient (ca 100%) even though deuterium incorporation can be decreased during work-up (85-90%). No exchange reaction was observed for aryl protons of aromatic ketones. (C) 2002 Elsevier Science Ltd. All rights reserved.

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页码：3789 / 3792

页数：4

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