Multisubunit RNA polymerases

被引：191

作者：

Cramer, P ^{[1
]}

机构：

[1] Univ Munich, Inst Biochem, Gene Ctr, D-81377 Munich, Germany

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 2002年 / 12卷 / 01期

关键词：

D O I：

10.1016/S0959-440X(02)00294-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Transcription of the genetic information in all cells is carried out by multisubunit RNA polymerases (RNAPs). Comparison of the crystal structures of a bacterial and a eukaryotic RNAP reveals a conserved core that comprises the active site and a multifunctional clamp. Together with a further structure of eukaryotic RNAP bound to DNA and RNA, these results elucidate many aspects of the transcription mechanism, including initiation, elongation, nucleotide addition, processivity and proofreading.

引用

页码：89 / 97

页数：9

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