A new eye on NLR proteins: focused on clarity or diffused by complexity?

被引：115

作者：

Bonardi, Vera ^{[1
]}

Cherkis, Karen ^{[1
,3
]}

Nishimura, Marc T. ^{[1
]}

Dangl, Jeffery L. ^{[1
,2
,3
,4
,5
]}

机构：

[1] Univ N Carolina, Dept Biol, Chapel Hill, NC 27599 USA

[2] Howard Hughes Med Inst, Chapel Hill, NC 27599 USA

[3] Univ N Carolina, Curriculum Genet & Mol Biol, Chapel Hill, NC 27599 USA

[4] Univ N Carolina, Dept Microbiol & Immunol, Chapel Hill, NC 27599 USA

[5] Univ N Carolina, Carolina Ctr Genome Sci, Chapel Hill, NC 27599 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2012年 / 24卷 / 01期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

DISEASE RESISTANCE PROTEIN; NB-LRR PROTEIN; IMMUNE-RECEPTOR RESISTANCE; TOBACCO-MOSAIC-VIRUS; OF-FUNCTION MUTATION; RICH REPEAT PROTEIN; CELL-DEATH; ATP BINDING; CONSTITUTIVE ACTIVATION; PATHOGEN RECOGNITION;

D O I：

10.1016/j.coi.2011.12.006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The nucleotide-binding domain /eucine-rich repeat proteins (NLRs) represent the major class of intracellular innate immune receptors in plants and animals. Understanding their functions is a major challenge in immunology. This review highlights recent efforts toward elucidating NLR functions in human and plants. We compare unconventional aspects of NLR proteins across the two kingdoms. We review recent advances describing P-loop independent activation, nuclear-cytoplasmic trafficking, oligonnerization and multimerization requirements for signaling, and for expanded functions beyond pathogen recognition by several NLR proteins.

引用

页码：41 / 50

页数：10

共 78 条

[31] Constitutive activation of a CC-NB-LRR protein alters morphogenesis through the cytokinin pathway in Arabidopsis [J].

Igari, Kadunari ;

Endo, Sachiko ;

Hibara, Ken-ichiro ;

Aida, Mitsuhiro ;

Sakakibara, Hitoshi ;

Kawasaki, Tsutomu ;

Tasaka, Masao .

PLANT JOURNAL, 2008, 55 (01) :14-27

[32] Evolutionary history and higher order classification of AAA plus ATPases [J].

Iyer, LM ;

Leipe, DD ;

Koonin, EV ;

Aravind, L .

JOURNAL OF STRUCTURAL BIOLOGY, 2004, 146 (1-2) :11-31

[33] Direct interaction of resistance gene and avirulence gene products confers rice blast resistance [J].

Jia, Y ;

McAdams, SA ;

Bryan, GT ;

Hershey, HP ;

Valent, B .

EMBO JOURNAL, 2000, 19 (15) :4004-4014

[34] The plant immune system [J].

Jones, Jonathan D. G. ;

Dangl, Jeffery L. .

NATURE, 2006, 444 (7117) :323-329

[35] Formation of apoptosome is initiated by cytochrome c-induced dATP hydrolysis and subsequent nucleotide exchange on Apaf-1 [J].

Kim, HE ;

Du, FH ;

Fang, M ;

Wang, XD .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (49) :17545-17550

[36] Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity [J].

Kofoed, Eric M. ;

Vance, Russell E. .

NATURE, 2011, 477 (7366) :592-U356

[37] Activation of an Arabidopsis Resistance Protein Is Specified by the in Planta Association of Its Leucine-Rich Repeat Domain with the Cognate Oomycete Effector [J].

Krasileva, Ksenia V. ;

Dahlbeck, Douglas ;

Staskawicz, Brian J. .

PLANT CELL, 2010, 22 (07) :2444-2458

[38] NLR functions beyond pathogen recognition [J].

Kufer, Thomas A. ;

Sansonetti, Philippe J. .

NATURE IMMUNOLOGY, 2011, 12 (02) :121-128

[39] The NOD2-RICK complex signals from the plasma membrane [J].

Lecine, Patrick ;

Esmiol, Sophie ;

Metais, Jean-Yves ;

Nicoletti, Cendrine ;

Nourry, Claire ;

McDonald, Christine ;

Nunez, Gabriel ;

Hugot, Jean-Pierre ;

Borg, Jean-Paul ;

Ollendorff, Vincent .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (20) :15197-15207

[40] NLR functions in plant and animal immune systems: so far and yet so close [J].

Maekawa, Takaki ;

Kufer, Thomas A. ;

Schulze-Lefert, Paul .

NATURE IMMUNOLOGY, 2011, 12 (09) :818-826

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