Studies on novel synthetic methodologies - Part 74 - An efficient synthesis of 2-benzoxepines from Morita-Baylis-Hillman adducts using heterogeneous recyclable catalysts

被引：13

作者：

Das, B ^{[1
]}

Majhi, A ^{[1
]}

Banerjee, J ^{[1
]}

Cowdhury, N ^{[1
]}

Holla, H ^{[1
]}

Harakishore, K ^{[1
]}

Murty, US ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Organ Chem Div 1, Hyderabad 500007, Andhra Pradesh, India

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2006年 / 54卷 / 03期

关键词：

2-benzoxepine; Morita-Baylis-Hillman adduct; formaldehyde; silica supported perchloric acid; Amberlyst-15; anti-bacterial activity;

D O I：

10.1248/cpb.54.403

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

2-Benzoxepines have efficiently been synthesized from Morita-Baylis-Hiliman adducts, alkyl 3-aryl-3-hydroxy-2-methylenepropanoates by treatment with HCHO catalyzed by silica supported perchloric acid (HClO4-SiO2)or Amberlyst-15 in CH2Cl2 under reflux for a short period of time (1.5-2.5h). The catalyst can be recovered and recycled. The antibacterial properties of the new 2-benzoxepines were studied but no activity was found.

引用

页码：403 / 405

页数：3

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