Identification and screening of carbapenemase-producing Enterobacteriaceae

被引：330

作者：

Nordmann, P. ^{[1
,2
]}

Gniadkowski, M. ^{[3
]}

Giske, C. G. ^{[4
]}

Poirel, L. ^{[1
,2
]}

Woodford, N. ^{[5
]}

Miriagou, V. ^{[6
]}

机构：

[1] Hop Bicetre, AP HP, INSERM Emerging Resistance Antibiot U914, Serv Bacteriol Virol,Fac Med, K Bicetre, France

[2] Univ Paris 11, K Bicetre, France

[3] Natl Med Inst, Dept Mol Microbiol, Warsaw, Poland

[4] Karolinska Inst, Karolinska Univ Hosp, Clin Microbiol MTC, Stockholm, Sweden

[5] Hlth Protect Agcy, Antibiot Resistance Monitoring & Reference Lab, London, England

[6] Hellenic Pasteur Inst, Bacteriol Lab, Athens, Greece

来源：

CLINICAL MICROBIOLOGY AND INFECTION | 2012年 / 18卷 / 05期

关键词：

Antibiotic; carbapenem; Gram-negatives; resistance; ss-lactams; MODIFIED HODGE TEST; KLEBSIELLA-PNEUMONIAE; BETA-LACTAMASES; RESISTANT ENTEROBACTERIACEAE; MULTIPLEX PCR; KPC; MECHANISMS; AGAR; CLOACAE; SPREAD;

D O I：

10.1111/j.1469-0691.2012.03815.x

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Carbapenem-hydrolysing beta-lactamases are the most powerful beta-lactamases, being able to hydrolyse almost all beta-lactams. They are mostly of the KPC, VIM, IMP, NDM and OXA-48 types. Their current extensive spread worldwide in Enterobacteriaceae is an important source of concern, as these carbapenemase producers are multidrug-resistant. Detection of infected patients and of carriers are the two main approaches for prevention of their spread. Phenotypic and molecular-based techniques are able to identify these carbapenemase producers, although with variable efficiencies. The detection of carriers still relies mostly on the use of screening culture media.

引用

页码：432 / 438

页数：7

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