miRo: a miRNA knowledge base

被引：51

作者：

Lagana, A. ^{[1
,2
]}

Forte, S. ^{[1
,2
]}

Giudice, A. ^{[2
]}

Arena, M. R. ^{[2
]}

Puglisi, P. L. ^{[2
]}

Giugno, R. ^{[2
]}

Pulvirenti, A. ^{[2
]}

Shasha, D. ^{[3
]}

Ferro, A. ^{[1
,2
]}

机构：

[1] Univ Catania, Dept Biomed Sci, I-95124 Catania, Italy

[2] Univ Catania, Dept Math & Comp Sci, I-95124 Catania, Italy

[3] NYU, Courant Inst Math Sci, New York, NY 10012 USA

来源：

DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION | 2009年

基金：

美国国家科学基金会;

关键词：

MICRORNA EXPRESSION; ALZHEIMERS-DISEASE; REVEALS; CLUSTER; PROLIFERATION; PROGRESSION; APOPTOSIS; MIR-17-92; CELLS; SITE;

D O I：

10.1093/database/bap008

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

miRo is a web-based knowledge base that provides users with miRNA-phenotype associations in humans. It integrates data from various online sources, such as databases of miRNAs, ontologies, diseases and targets, into a unified database equipped with an intuitive and flexible query interface and data mining facilities. The main goal of miRo is the establishment of a knowledge base which allows non-trivial analysis through sophisticated mining techniques and the introduction of a new layer of associations between genes and phenotypes inferred based on miRNAs annotations. Furthermore, a specificity function applied to validated data highlights the most significant associations. The miRo` web site is available at: http://ferrolab.dmi.unict.it/miro. Database URL: http://ferrolab.dmi.unict.it/miro

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