A prototype continuous-flow liquid-liquid extraction system using open-source technology

被引：94

作者：

O'Brien, Matthew ^{[1
,2
]}

Koos, Peter ^{[1
]}

Browne, Duncan L. ^{[1
]}

Ley, Steven V. ^{[1
]}

机构：

[1] Univ Cambridge, Dept Chem, Whiffen Lab, Cambridge CB2 1EW, England

[2] Keele Univ, Keele ST5 5BG, Staffs, England

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2012年 / 10卷 / 35期

基金：

英国工程与自然科学研究理事会;

关键词：

MULTISTEP ORGANIC-SYNTHESIS; FLUOROUS BIPHASIC SYSTEM; PROCESS INTENSIFICATION; PHASE SEPARATOR; INJECTION; CHEMISTRY; DISPERSION; RESOLUTION; ALDEHYDES; LIBRARY;

D O I：

10.1039/c2ob25912e

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A prototype continuous-flow liquid-liquid extraction system is reported. By harnessing several open-source software libraries, a computer control script was written using the Python programming language. Using a 'computer-vision' approach, this allowed the computer to monitor the interface level between the organic and aqueous phases using a simple webcam setup and (by dynamically controlling pump flow rate) to keep this interface within defined limits. The system enabled the efficient 'inline' extraction of excess reagent in hydrazone formations, dithiane formations and epoxidations. The initial results of dispersion measurement are also presented.

引用

页码：7031 / 7036

页数：6

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