microRNAs in skeletal muscle differentiation and disease

被引:72
作者
Goljanek-Whysall, Katarzyna [1 ]
Sweetman, Dylan [2 ]
Muensterberg, Andrea E. [1 ]
机构
[1] Univ E Anglia, Sch Biol Sci, Norwich NR4 7TJ, Norfolk, England
[2] Univ Nottingham, Sch Biosci, Div Anim Sci, Loughborough LE12 5RD, Leics, England
基金
英国生物技术与生命科学研究理事会;
关键词
microRNA; muscle-associated disease; muscle-specific miRNA (myomiR); muscular dystrophy; non-coding RNA; skeletal muscle; MESSENGER-RNAS; IN-VIVO; BIOGENESIS PATHWAYS; WIDE IDENTIFICATION; ENDURANCE EXERCISE; GENE-REGULATION; MYOMIR NETWORK; EXPRESSION; MIR-206; MIRNA;
D O I
10.1042/CS20110634
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
miRNAs (microRNAs) are novel post-transcriptional regulators of gene expression. Several miRNAs, expressed exclusively in muscle, play important roles during muscle development, growth and regeneration; other ubiquitously expressed miRNAs are also essential for muscle function. In the present review, we outline the miRNAs involved in embryonic muscle development and those that have been found to be dysregulated in diseases associated with skeletal muscle or are changed during muscle adaptation. miRNAs are promising biomarkers and candidates for potential therapeutic intervention. We discuss the strategies that aim to develop novel therapies through modulating miRNA activity. In time, some of these approaches may become available to treat muscle-associated diseases.
引用
收藏
页码:611 / 625
页数:15
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