Physical Activity in Preventing Alzheimer's Disease and Cognitive Decline: A Narrative Review

被引：39

作者：

Brini, Stefano ^{[1
,2
,7
]}

Sohrabi, Hamid R. ^{[3
,4
,6
]}

Peiffer, Jeremiah J. ^{[1
]}

Karrasch, Mira ^{[5
]}

Hamalainen, Heikki ^{[2
,7
]}

Martins, Ralph N. ^{[3
,4
,6
]}

Fairchild, Timothy J. ^{[1
]}

机构：

[1] Murdoch Univ, Sch Psychol & Exercise Sci, Room 2-042,Social Sci Bldg,90 South St, Perth, WA 6150, Australia

[2] Univ Turku, Dept Psychol & Speech Language Pathol, Turku, Finland

[3] Edith Cowan Univ, Sch Med & Hlth Sci, Perth, WA, Australia

[4] Macquarie Univ, Dept Biomed Sci, Sydney, NSW, Australia

[5] Abo Akad Univ, Dept Psychol, Turku, Finland

[6] Australian Alzheimers Res Fdn, Perth, WA, Australia

[7] Univ Turku, Turku Brain & Mind Ctr, Turku, Finland

来源：

SPORTS MEDICINE | 2018年 / 48卷 / 01期

关键词：

CARDIOVASCULAR RISK-FACTORS; NEUROTROPHIC FACTOR LEVELS; SEDENTARY LIFE-STYLE; BDNF MESSENGER-RNA; APOLIPOPROTEIN-E; OLDER-ADULTS; MEMORY COMPLAINTS; ASSOCIATION WORKGROUPS; DIAGNOSTIC GUIDELINES; NATIONAL INSTITUTE;

D O I：

10.1007/s40279-017-0787-y

中图分类号：

G8 [体育];

学科分类号：

04 ; 0403 ;

摘要：

A large body of epidemiological and experimental data exploring the relationship between physical activity (PA) and Alzheimer's disease (AD) are now available. Despite observational evidence supporting a role for PA in delaying the onset of AD, randomised controlled trials have reported mixed findings, likely due to the heterogeneity in study cohorts, outcome measures, and the adopted PA intervention. The primary objective of this narrative review is to evaluate the extant evidence on the relationship between PA, cognitive decline and AD in older populations. The interaction between PA and the putative mechanisms underlying AD progression, including genetic factors and amyloid-beta levels will be explored. In this context, particular attention will be given to studies assessing PA in the early clinical and preclinical, asymptomatic stages of AD. Based on current evidence, clinical considerations for implementation of exercise-based interventions are discussed, along with limitations of previous research and directions for future studies.

引用

页码：29 / 44

页数：16

共 161 条

[11] A 9-Week Aerobic and Strength Training Program Improves Cognitive and Motor Function in Patients with Dementia: A Randomized, Controlled Trial [J].

Bossers, Willem J. R. ;

van der Woude, Lucas H. V. ;

Boersma, Froukje ;

Hortobagyi, Tibor ;

Scherder, Erik J. A. ;

van Heuvelen, Marieke J. G. .

AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY, 2015, 23 (11) :1106-1116

[12] Physical activity and amyloid-β plasma and brain levels: results from the Australian Imaging, Biomarkers and Lifestyle Study of Ageing [J].

Brown, B. M. ;

Peiffer, J. J. ;

Taddei, K. ;

Lui, J. K. ;

Laws, S. M. ;

Gupta, V. B. ;

Taddei, T. ;

Ward, V. K. ;

Rodrigues, M. A. ;

Burnham, S. ;

Rainey-Smith, S. R. ;

Villemagne, V. L. ;

Bush, A. ;

Ellis, K. A. ;

Masters, C. L. ;

Ames, D. ;

Macaulay, S. L. ;

Szoeke, C. ;

Rowe, C. C. ;

Martins, R. N. .

MOLECULAR PSYCHIATRY, 2013, 18 (08) :875-881

[13] Total daily physical activity and the risk of AD and cognitive decline in older adults [J].

Buchman, A. S. ;

Boyle, P. A. ;

Yu, L. ;

Shah, R. C. ;

Wilson, R. S. ;

Bennett, D. A. .

NEUROLOGY, 2012, 78 (17) :1323-1329

[14] Relationship of serum brain-derived neurotrophic factor (BDNF) and health-related lifestyle in healthy human subjects [J].

Chan, Ka Lok ;

Tong, Kai Yu ;

Yip, Shea Ping .

NEUROSCIENCE LETTERS, 2008, 447 (2-3) :124-128

[15] Physical therapy intervention (PTI) increases plasma brain-derived neurotrophic factor (BDNF) levels in non-frail and pre-frail elderly women [J].

Coelho, F. M. ;

Pereira, D. S. ;

Lustosa, L. P. ;

Silva, J. P. ;

Dias, J. M. D. ;

Dias, R. C. D. ;

Queiroz, B. Z. ;

Teixeira, A. L. ;

Teixeira, M. M. ;

Pereira, L. S. M. .

ARCHIVES OF GERONTOLOGY AND GERIATRICS, 2012, 54 (03) :415-420

[16] Increased basal plasma brain-derived neurotrophic factor levels in sprint runners [J].

Correia, Paulo Roberto ;

Scorza, Fulvio Alexandre ;

da Silva, Sergio Gomes ;

Pansani, Aline ;

Toscano-Silva, Michelle ;

de Almeida, Antonio Carlos ;

Arida, Ricardo Mario .

NEUROSCIENCE BULLETIN, 2011, 27 (05) :325-329

[17] Acute strength exercise and the involvement of small or large muscle mass on plasma brain-derived neurotrophic factor levels [J].

Correia, Paulo Roberto ;

Pansani, Aline ;

Machado, Felipe ;

Andrade, Marilia ;

da Silva, Antonio Carlos ;

Scorza, Fulvio Alexandre ;

Cavalheiro, Esper Abrao ;

Arida, Ricardo Mario .

CLINICS, 2010, 65 (11) :1123-1126

[18] Examining the Relationship Between Subjective and Objective Memory Performance in Older Adults: A Meta-Analysis [J].

Crumley, Jessica J. ;

Stetler, Cinnamon A. ;

Horhota, Michelle .

PSYCHOLOGY AND AGING, 2014, 29 (02) :250-263

[19] Cognitive decline and dementia in diabetes - systematic overview of prospective observational studies [J].

Cukierman, T ;

Gerstein, HC ;

Williamson, JD .

DIABETOLOGIA, 2005, 48 (12) :2460-2469

[20] Cardiovascular risk factors and future risk of Alzheimer's disease [J].

de Bruijn, Renee F. A. G. ;

Ikram, M. Arfan .

BMC MEDICINE, 2014, 12

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