Quantitative proteomics as a new piece of the systems biology puzzle

被引：62

作者：

Bachi, Angela ^{[2
]}

Bonaldi, Tiziana ^{[1
]}

机构：

[1] European Inst Oncol, Dept Expt Oncol, I-20139 Milan, Italy

[2] Ist Sci San Raffaele, DIBIT, I-20132 Milan, Italy

来源：

JOURNAL OF PROTEOMICS | 2008年 / 71卷 / 03期

关键词：

Quantitative proteomics; Mass spectrometry; Stable-isotope labeling; System biology; Gene-phenotypization;

D O I：

10.1016/j.jprot.2008.07.001

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The definition of the role of each gene product in its cellular context is of outstanding importance in the post-genomics era. Recent technological innovations have driven research in proteomics from single protein characterization to global approaches, aiming to achieve a comprehensive qualitative and quantitative description of complex molecular mechanisms. In this review, we discuss the methodology of quantitative proteomics as it applies to the analysis of complex biological model systems. A special attention will be given to model systems that are suitable for functional genomic studies, where the potential of quantitative proteomics can be effectively demonstrated. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：357 / 367

页数：11

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