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Vaccine-induced cellular immune responses reduce plasma viral concentrations after repeated low-dose challenge with pathogenic simian immunodeficiency virus SIVmac239
被引:209
作者:

Wilson, Nancy A.
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机构: Univ Wisconsin, Natl Primate Res Ctr, Madison, WI 53711 USA

Reed, Jason
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机构: Univ Wisconsin, Natl Primate Res Ctr, Madison, WI 53711 USA

Napoe, Gnankan S.
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机构: Univ Wisconsin, Natl Primate Res Ctr, Madison, WI 53711 USA

Piaskowski, Shari
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机构: Univ Wisconsin, Natl Primate Res Ctr, Madison, WI 53711 USA

Szymanski, Andy
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机构: Univ Wisconsin, Natl Primate Res Ctr, Madison, WI 53711 USA

Furlott, Jessica
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Gonzalez, Edna J.
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Yant, Levi J.
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Maness, Nicholas J.
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May, Gemma E.
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Soma, Taeko
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机构: Univ Wisconsin, Natl Primate Res Ctr, Madison, WI 53711 USA

Reynolds, Matthew R.
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Rakasz, Eva
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Rudersdorf, Richard
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McDermott, Adrian B.
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O'Connor, David H.
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Friedrich, Thomas C.
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Allison, David B.
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Patki, Amit
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Picker, Louis J.
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Burton, Dennis R.
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Lin, Jing
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Huang, Lingyi
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Patel, Deepa
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Heindecker, Gwendolyn
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Fan, Jiang
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Citron, Michael
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Horton, Melanie
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Wang, Fubao
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机构: Univ Wisconsin, Natl Primate Res Ctr, Madison, WI 53711 USA

Liang, Xiaoping
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机构: Univ Wisconsin, Natl Primate Res Ctr, Madison, WI 53711 USA

Shiver, John W.
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机构: Univ Wisconsin, Natl Primate Res Ctr, Madison, WI 53711 USA

Casimiro, Danilo R.
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h-index: 0
机构: Univ Wisconsin, Natl Primate Res Ctr, Madison, WI 53711 USA

Watkins, David I.
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机构: Univ Wisconsin, Natl Primate Res Ctr, Madison, WI 53711 USA
机构:
[1] Univ Wisconsin, Natl Primate Res Ctr, Madison, WI 53711 USA
[2] Univ Wisconsin, Dept Pathol & Lab Med, Madison, WI USA
[3] Univ Alabama Birmingham, Dept Biostat, Sect Stat Genet, Birmingham, AL 35294 USA
[4] Oregon Hlth & Sci Univ, Vaccine & Gene Therapy Inst, Dept Pathol, Beaverton, OR 97006 USA
[5] Oregon Hlth & Sci Univ, Dept Mol Microbiol & Immunol, Beaverton, OR 97006 USA
[6] Scripps Res Inst, Dept Immunol, La Jolla, CA 92037 USA
[7] Scripps Res Inst, Dept Mol Biol, La Jolla, CA 92037 USA
[8] Merck Res Labs, West Point, PA 19486 USA
关键词:
D O I:
10.1128/JVI.00171-06
中图分类号:
Q93 [微生物学];
学科分类号:
071005 ;
100705 ;
摘要:
The goal of an AIDS vaccine regimen designed to induce cellular immune responses should be to reduce the viral set point and preserve memory CD4 lymphocytes. Here we investigated whether vaccine-induced cellular immunity in the absence of any Env-specific antibodies can control viral replication following multiple low-dose challenges with the highly pathogenic SIVmac239 isolate. Eight Mamu-A*01-positive Indian rhesus macaques were vaccinated with simian immunodeficiency virus (SIV) gag, tat, rev, and nef using a DNA prime-adenovirus boost strategy. Peak viremia (P = 0.007) and the chronic phase set point (P = 0.0192) were significantly decreased in the vaccinated cohort, out to I year postinfection. Loss of CD4(+) memory populations was also ameliorated in vaccinated animals. Interestingly, only one of the eight vaccinees developed Env-specific neutralizing antibodies after infection. The control observed was significantly improved over that observed in animals vaccinated with SIV gag only. Vaccine-induced cellular immune responses can, therefore, exert a measure of control over replication of the AIDS virus in the complete absence of neutralizing antibody and give us hope that a vaccine designed to induce cellular immune responses might control viral replication.
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页码:5875 / 5885
页数:11
相关论文
共 69 条
[51]
Development and homeostasis of T cell memory in rhesus macaque
[J].
Pitcher, CJ
;
Hagen, SI
;
Walker, JM
;
Lum, R
;
Mitchell, BL
;
Maino, VC
;
Axthelm, MK
;
Picker, LJ
.
JOURNAL OF IMMUNOLOGY,
2002, 168 (01)
:29-43

Pitcher, CJ
论文数: 0 引用数: 0
h-index: 0
机构: Oregon Hlth & Sci Univ, Vaccine & Gene Therapy Inst, Oregon Reg Primate Res Ctr, Beaverton, OR 97006 USA

Hagen, SI
论文数: 0 引用数: 0
h-index: 0
机构: Oregon Hlth & Sci Univ, Vaccine & Gene Therapy Inst, Oregon Reg Primate Res Ctr, Beaverton, OR 97006 USA

论文数: 引用数:
h-index:
机构:

Lum, R
论文数: 0 引用数: 0
h-index: 0
机构: Oregon Hlth & Sci Univ, Vaccine & Gene Therapy Inst, Oregon Reg Primate Res Ctr, Beaverton, OR 97006 USA

Mitchell, BL
论文数: 0 引用数: 0
h-index: 0
机构: Oregon Hlth & Sci Univ, Vaccine & Gene Therapy Inst, Oregon Reg Primate Res Ctr, Beaverton, OR 97006 USA

Maino, VC
论文数: 0 引用数: 0
h-index: 0
机构: Oregon Hlth & Sci Univ, Vaccine & Gene Therapy Inst, Oregon Reg Primate Res Ctr, Beaverton, OR 97006 USA

Axthelm, MK
论文数: 0 引用数: 0
h-index: 0
机构: Oregon Hlth & Sci Univ, Vaccine & Gene Therapy Inst, Oregon Reg Primate Res Ctr, Beaverton, OR 97006 USA

Picker, LJ
论文数: 0 引用数: 0
h-index: 0
机构: Oregon Hlth & Sci Univ, Vaccine & Gene Therapy Inst, Oregon Reg Primate Res Ctr, Beaverton, OR 97006 USA
[52]
Viral load and heterosexual transmission of human immunodeficiency virus type 1
[J].
Quinn, TC
;
Wawer, MJ
;
Sewankambo, N
;
Serwadda, D
;
Li, CJ
;
Wabwire-Mangen, F
;
Meehan, MO
;
Lutalo, T
;
Gray, RH
.
NEW ENGLAND JOURNAL OF MEDICINE,
2000, 342 (13)
:921-929

Quinn, TC
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Univ, Div Infect Dis, Baltimore, MD 21205 USA

Wawer, MJ
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Univ, Div Infect Dis, Baltimore, MD 21205 USA

Sewankambo, N
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Univ, Div Infect Dis, Baltimore, MD 21205 USA

Serwadda, D
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Univ, Div Infect Dis, Baltimore, MD 21205 USA

Li, CJ
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Univ, Div Infect Dis, Baltimore, MD 21205 USA

Wabwire-Mangen, F
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Univ, Div Infect Dis, Baltimore, MD 21205 USA

Meehan, MO
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Univ, Div Infect Dis, Baltimore, MD 21205 USA

Lutalo, T
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Univ, Div Infect Dis, Baltimore, MD 21205 USA

Gray, RH
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Univ, Div Infect Dis, Baltimore, MD 21205 USA
[53]
Deliberate removal of T cell help improves virus-neutralizing antibody production
[J].
Recher, M
;
Lang, KS
;
Hunziker, L
;
Freigang, S
;
Eschli, B
;
Harris, NL
;
Navarini, A
;
Senn, BM
;
Fink, K
;
Lötscher, M
;
Hangartner, L
;
Zellweger, R
;
Hersberger, M
;
Theocharides, A
;
Hengartner, H
;
Zinkernagel, RM
.
NATURE IMMUNOLOGY,
2004, 5 (09)
:934-942

Recher, M
论文数: 0 引用数: 0
h-index: 0
机构: Univ Zurich Hosp, Inst Expt Immunol, CH-8091 Zurich, Switzerland

Lang, KS
论文数: 0 引用数: 0
h-index: 0
机构: Univ Zurich Hosp, Inst Expt Immunol, CH-8091 Zurich, Switzerland

Hunziker, L
论文数: 0 引用数: 0
h-index: 0
机构: Univ Zurich Hosp, Inst Expt Immunol, CH-8091 Zurich, Switzerland

Freigang, S
论文数: 0 引用数: 0
h-index: 0
机构: Univ Zurich Hosp, Inst Expt Immunol, CH-8091 Zurich, Switzerland

Eschli, B
论文数: 0 引用数: 0
h-index: 0
机构: Univ Zurich Hosp, Inst Expt Immunol, CH-8091 Zurich, Switzerland

Harris, NL
论文数: 0 引用数: 0
h-index: 0
机构: Univ Zurich Hosp, Inst Expt Immunol, CH-8091 Zurich, Switzerland

Navarini, A
论文数: 0 引用数: 0
h-index: 0
机构: Univ Zurich Hosp, Inst Expt Immunol, CH-8091 Zurich, Switzerland

Senn, BM
论文数: 0 引用数: 0
h-index: 0
机构: Univ Zurich Hosp, Inst Expt Immunol, CH-8091 Zurich, Switzerland

Fink, K
论文数: 0 引用数: 0
h-index: 0
机构: Univ Zurich Hosp, Inst Expt Immunol, CH-8091 Zurich, Switzerland

Lötscher, M
论文数: 0 引用数: 0
h-index: 0
机构: Univ Zurich Hosp, Inst Expt Immunol, CH-8091 Zurich, Switzerland

Hangartner, L
论文数: 0 引用数: 0
h-index: 0
机构: Univ Zurich Hosp, Inst Expt Immunol, CH-8091 Zurich, Switzerland

Zellweger, R
论文数: 0 引用数: 0
h-index: 0
机构: Univ Zurich Hosp, Inst Expt Immunol, CH-8091 Zurich, Switzerland

Hersberger, M
论文数: 0 引用数: 0
h-index: 0
机构: Univ Zurich Hosp, Inst Expt Immunol, CH-8091 Zurich, Switzerland

Theocharides, A
论文数: 0 引用数: 0
h-index: 0
机构: Univ Zurich Hosp, Inst Expt Immunol, CH-8091 Zurich, Switzerland

Hengartner, H
论文数: 0 引用数: 0
h-index: 0
机构: Univ Zurich Hosp, Inst Expt Immunol, CH-8091 Zurich, Switzerland

Zinkernagel, RM
论文数: 0 引用数: 0
h-index: 0
机构: Univ Zurich Hosp, Inst Expt Immunol, CH-8091 Zurich, Switzerland
[54]
An effective AIDS vaccine based on live attenuated vesicular stomatitis virus recombinants
[J].
Rose, NF
;
Marx, PA
;
Luckay, A
;
Nixon, DF
;
Moretto, WJ
;
Donahoe, SM
;
Montefiori, D
;
Roberts, A
;
Buonocore, L
;
Rose, JK
.
CELL,
2001, 106 (05)
:539-549

Rose, NF
论文数: 0 引用数: 0
h-index: 0
机构: Yale Univ, Sch Med, Dept Pathol, New Haven, CT 06510 USA

Marx, PA
论文数: 0 引用数: 0
h-index: 0
机构: Yale Univ, Sch Med, Dept Pathol, New Haven, CT 06510 USA

Luckay, A
论文数: 0 引用数: 0
h-index: 0
机构: Yale Univ, Sch Med, Dept Pathol, New Haven, CT 06510 USA

Nixon, DF
论文数: 0 引用数: 0
h-index: 0
机构: Yale Univ, Sch Med, Dept Pathol, New Haven, CT 06510 USA

Moretto, WJ
论文数: 0 引用数: 0
h-index: 0
机构: Yale Univ, Sch Med, Dept Pathol, New Haven, CT 06510 USA

Donahoe, SM
论文数: 0 引用数: 0
h-index: 0
机构: Yale Univ, Sch Med, Dept Pathol, New Haven, CT 06510 USA

Montefiori, D
论文数: 0 引用数: 0
h-index: 0
机构: Yale Univ, Sch Med, Dept Pathol, New Haven, CT 06510 USA

Roberts, A
论文数: 0 引用数: 0
h-index: 0
机构: Yale Univ, Sch Med, Dept Pathol, New Haven, CT 06510 USA

Buonocore, L
论文数: 0 引用数: 0
h-index: 0
机构: Yale Univ, Sch Med, Dept Pathol, New Haven, CT 06510 USA

Rose, JK
论文数: 0 引用数: 0
h-index: 0
机构:
Yale Univ, Sch Med, Dept Pathol, New Haven, CT 06510 USA Yale Univ, Sch Med, Dept Pathol, New Haven, CT 06510 USA
[55]
Vigorous HIV-1-specific CD4(+) T cell responses associated with control of viremia
[J].
Rosenberg, ES
;
Billingsley, JM
;
Caliendo, AM
;
Boswell, SL
;
Sax, PE
;
Kalams, SA
;
Walker, BD
.
SCIENCE,
1997, 278 (5342)
:1447-1450

Rosenberg, ES
论文数: 0 引用数: 0
h-index: 0
机构: MASSACHUSETTS GEN HOSP, PARTNERS AIDS RES CTR, BOSTON, MA 02114 USA

Billingsley, JM
论文数: 0 引用数: 0
h-index: 0
机构: MASSACHUSETTS GEN HOSP, PARTNERS AIDS RES CTR, BOSTON, MA 02114 USA

Caliendo, AM
论文数: 0 引用数: 0
h-index: 0
机构: MASSACHUSETTS GEN HOSP, PARTNERS AIDS RES CTR, BOSTON, MA 02114 USA

Boswell, SL
论文数: 0 引用数: 0
h-index: 0
机构: MASSACHUSETTS GEN HOSP, PARTNERS AIDS RES CTR, BOSTON, MA 02114 USA

Sax, PE
论文数: 0 引用数: 0
h-index: 0
机构: MASSACHUSETTS GEN HOSP, PARTNERS AIDS RES CTR, BOSTON, MA 02114 USA

Kalams, SA
论文数: 0 引用数: 0
h-index: 0
机构: MASSACHUSETTS GEN HOSP, PARTNERS AIDS RES CTR, BOSTON, MA 02114 USA

Walker, BD
论文数: 0 引用数: 0
h-index: 0
机构: MASSACHUSETTS GEN HOSP, PARTNERS AIDS RES CTR, BOSTON, MA 02114 USA
[56]
Endocytosis of major histocompatibility complex class I molecules is induced by the HIV-1 Nef protein
[J].
Schwartz, O
;
Marechal, V
;
LeGall, S
;
Lemonnier, F
;
Heard, JM
.
NATURE MEDICINE,
1996, 2 (03)
:338-342

论文数: 引用数:
h-index:
机构:

Marechal, V
论文数: 0 引用数: 0
h-index: 0
机构:
INST PASTEUR,UNITE IMMUNITE CELLULAIRE ANTIVIRALE,F-75724 PARIS 15,FRANCE INST PASTEUR,UNITE IMMUNITE CELLULAIRE ANTIVIRALE,F-75724 PARIS 15,FRANCE

LeGall, S
论文数: 0 引用数: 0
h-index: 0
机构:
INST PASTEUR,UNITE IMMUNITE CELLULAIRE ANTIVIRALE,F-75724 PARIS 15,FRANCE INST PASTEUR,UNITE IMMUNITE CELLULAIRE ANTIVIRALE,F-75724 PARIS 15,FRANCE

Lemonnier, F
论文数: 0 引用数: 0
h-index: 0
机构:
INST PASTEUR,UNITE IMMUNITE CELLULAIRE ANTIVIRALE,F-75724 PARIS 15,FRANCE INST PASTEUR,UNITE IMMUNITE CELLULAIRE ANTIVIRALE,F-75724 PARIS 15,FRANCE

Heard, JM
论文数: 0 引用数: 0
h-index: 0
机构:
INST PASTEUR,UNITE IMMUNITE CELLULAIRE ANTIVIRALE,F-75724 PARIS 15,FRANCE INST PASTEUR,UNITE IMMUNITE CELLULAIRE ANTIVIRALE,F-75724 PARIS 15,FRANCE
[57]
Replication-incompetent adenoviral vaccine vector elicits effective anti-immunodeficiency-virus immunity
[J].
Shiver, JW
;
Fu, TM
;
Chen, L
;
Casimiro, DR
;
Davies, ME
;
Evans, RK
;
Zhang, ZQ
;
Simon, AJ
;
Trigona, WL
;
Dubey, SA
;
Huang, LY
;
Harris, VA
;
Long, RS
;
Liang, XP
;
Handt, L
;
Schleif, WA
;
Zhu, L
;
Freed, DC
;
Persaud, NV
;
Guan, L
;
Punt, KS
;
Tang, A
;
Chen, MC
;
Wilson, KA
;
Collins, KB
;
Heidecker, GJ
;
Fernandez, VR
;
Perry, HC
;
Joyce, JG
;
Grimm, KM
;
Cook, JC
;
Keller, PM
;
Kresock, DS
;
Mach, H
;
Troutman, RD
;
Isopi, LA
;
Williams, DM
;
Xu, Z
;
Bohannon, KE
;
Volkin, DB
;
Montefiori, DC
;
Miura, A
;
Krivulka, GR
;
Lifton, MA
;
Kuroda, MJ
;
Schmitz, JE
;
Letvin, NL
;
Caulfield, MJ
;
Bett, AJ
;
Youil, R
.
NATURE,
2002, 415 (6869)
:331-335

Shiver, JW
论文数: 0 引用数: 0
h-index: 0
机构: Merck Res Labs, W Point, PA 19486 USA

Fu, TM
论文数: 0 引用数: 0
h-index: 0
机构: Merck Res Labs, W Point, PA 19486 USA

Chen, L
论文数: 0 引用数: 0
h-index: 0
机构: Merck Res Labs, W Point, PA 19486 USA

Casimiro, DR
论文数: 0 引用数: 0
h-index: 0
机构: Merck Res Labs, W Point, PA 19486 USA

Davies, ME
论文数: 0 引用数: 0
h-index: 0
机构: Merck Res Labs, W Point, PA 19486 USA

Evans, RK
论文数: 0 引用数: 0
h-index: 0
机构: Merck Res Labs, W Point, PA 19486 USA

Zhang, ZQ
论文数: 0 引用数: 0
h-index: 0
机构: Merck Res Labs, W Point, PA 19486 USA

Simon, AJ
论文数: 0 引用数: 0
h-index: 0
机构: Merck Res Labs, W Point, PA 19486 USA

Trigona, WL
论文数: 0 引用数: 0
h-index: 0
机构: Merck Res Labs, W Point, PA 19486 USA

Dubey, SA
论文数: 0 引用数: 0
h-index: 0
机构: Merck Res Labs, W Point, PA 19486 USA

Huang, LY
论文数: 0 引用数: 0
h-index: 0
机构: Merck Res Labs, W Point, PA 19486 USA

Harris, VA
论文数: 0 引用数: 0
h-index: 0
机构: Merck Res Labs, W Point, PA 19486 USA

Long, RS
论文数: 0 引用数: 0
h-index: 0
机构: Merck Res Labs, W Point, PA 19486 USA

Liang, XP
论文数: 0 引用数: 0
h-index: 0
机构: Merck Res Labs, W Point, PA 19486 USA

Handt, L
论文数: 0 引用数: 0
h-index: 0
机构: Merck Res Labs, W Point, PA 19486 USA

Schleif, WA
论文数: 0 引用数: 0
h-index: 0
机构: Merck Res Labs, W Point, PA 19486 USA

Zhu, L
论文数: 0 引用数: 0
h-index: 0
机构: Merck Res Labs, W Point, PA 19486 USA

Freed, DC
论文数: 0 引用数: 0
h-index: 0
机构: Merck Res Labs, W Point, PA 19486 USA

Persaud, NV
论文数: 0 引用数: 0
h-index: 0
机构: Merck Res Labs, W Point, PA 19486 USA

Guan, L
论文数: 0 引用数: 0
h-index: 0
机构: Merck Res Labs, W Point, PA 19486 USA

Punt, KS
论文数: 0 引用数: 0
h-index: 0
机构: Merck Res Labs, W Point, PA 19486 USA

Tang, A
论文数: 0 引用数: 0
h-index: 0
机构: Merck Res Labs, W Point, PA 19486 USA

Chen, MC
论文数: 0 引用数: 0
h-index: 0
机构: Merck Res Labs, W Point, PA 19486 USA

Wilson, KA
论文数: 0 引用数: 0
h-index: 0
机构: Merck Res Labs, W Point, PA 19486 USA

Collins, KB
论文数: 0 引用数: 0
h-index: 0
机构: Merck Res Labs, W Point, PA 19486 USA

Heidecker, GJ
论文数: 0 引用数: 0
h-index: 0
机构: Merck Res Labs, W Point, PA 19486 USA

Fernandez, VR
论文数: 0 引用数: 0
h-index: 0
机构: Merck Res Labs, W Point, PA 19486 USA

Perry, HC
论文数: 0 引用数: 0
h-index: 0
机构: Merck Res Labs, W Point, PA 19486 USA

Joyce, JG
论文数: 0 引用数: 0
h-index: 0
机构: Merck Res Labs, W Point, PA 19486 USA

Grimm, KM
论文数: 0 引用数: 0
h-index: 0
机构: Merck Res Labs, W Point, PA 19486 USA

Cook, JC
论文数: 0 引用数: 0
h-index: 0
机构: Merck Res Labs, W Point, PA 19486 USA

Keller, PM
论文数: 0 引用数: 0
h-index: 0
机构: Merck Res Labs, W Point, PA 19486 USA

Kresock, DS
论文数: 0 引用数: 0
h-index: 0
机构: Merck Res Labs, W Point, PA 19486 USA

Mach, H
论文数: 0 引用数: 0
h-index: 0
机构: Merck Res Labs, W Point, PA 19486 USA

Troutman, RD
论文数: 0 引用数: 0
h-index: 0
机构: Merck Res Labs, W Point, PA 19486 USA

Isopi, LA
论文数: 0 引用数: 0
h-index: 0
机构: Merck Res Labs, W Point, PA 19486 USA

Williams, DM
论文数: 0 引用数: 0
h-index: 0
机构: Merck Res Labs, W Point, PA 19486 USA

Xu, Z
论文数: 0 引用数: 0
h-index: 0
机构: Merck Res Labs, W Point, PA 19486 USA

Bohannon, KE
论文数: 0 引用数: 0
h-index: 0
机构: Merck Res Labs, W Point, PA 19486 USA

Volkin, DB
论文数: 0 引用数: 0
h-index: 0
机构: Merck Res Labs, W Point, PA 19486 USA

Montefiori, DC
论文数: 0 引用数: 0
h-index: 0
机构: Merck Res Labs, W Point, PA 19486 USA

Miura, A
论文数: 0 引用数: 0
h-index: 0
机构: Merck Res Labs, W Point, PA 19486 USA

Krivulka, GR
论文数: 0 引用数: 0
h-index: 0
机构: Merck Res Labs, W Point, PA 19486 USA

Lifton, MA
论文数: 0 引用数: 0
h-index: 0
机构: Merck Res Labs, W Point, PA 19486 USA

Kuroda, MJ
论文数: 0 引用数: 0
h-index: 0
机构: Merck Res Labs, W Point, PA 19486 USA

Schmitz, JE
论文数: 0 引用数: 0
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机构: Merck Res Labs, W Point, PA 19486 USA

Letvin, NL
论文数: 0 引用数: 0
h-index: 0
机构: Merck Res Labs, W Point, PA 19486 USA

Caulfield, MJ
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h-index: 0
机构: Merck Res Labs, W Point, PA 19486 USA

Bett, AJ
论文数: 0 引用数: 0
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机构: Merck Res Labs, W Point, PA 19486 USA

Youil, R
论文数: 0 引用数: 0
h-index: 0
机构: Merck Res Labs, W Point, PA 19486 USA
[58]
Comparison of the efficacy of early versus late viral proteins in vaccination against SIV
[J].
Stittelaar, KJ
;
Gruters, RA
;
Schutten, M
;
van Baalen, CA
;
van Amerongen, G
;
Cranage, M
;
Liljeström, P
;
Sutter, G
;
Osterhaus, ADME
.
VACCINE,
2002, 20 (23-24)
:2921-2927

Stittelaar, KJ
论文数: 0 引用数: 0
h-index: 0
机构: GSF, Inst Mol Virol, D-85764 Neuherberg, Germany

Gruters, RA
论文数: 0 引用数: 0
h-index: 0
机构: GSF, Inst Mol Virol, D-85764 Neuherberg, Germany

Schutten, M
论文数: 0 引用数: 0
h-index: 0
机构: GSF, Inst Mol Virol, D-85764 Neuherberg, Germany

van Baalen, CA
论文数: 0 引用数: 0
h-index: 0
机构: GSF, Inst Mol Virol, D-85764 Neuherberg, Germany

van Amerongen, G
论文数: 0 引用数: 0
h-index: 0
机构: GSF, Inst Mol Virol, D-85764 Neuherberg, Germany

Cranage, M
论文数: 0 引用数: 0
h-index: 0
机构: GSF, Inst Mol Virol, D-85764 Neuherberg, Germany

Liljeström, P
论文数: 0 引用数: 0
h-index: 0
机构: GSF, Inst Mol Virol, D-85764 Neuherberg, Germany

Sutter, G
论文数: 0 引用数: 0
h-index: 0
机构: GSF, Inst Mol Virol, D-85764 Neuherberg, Germany

Osterhaus, ADME
论文数: 0 引用数: 0
h-index: 0
机构: GSF, Inst Mol Virol, D-85764 Neuherberg, Germany
[59]
A pathogenic threshold of virus load defined in simian immunodeficiency virus- or simian-human immunodeficiency virus-infected macaques
[J].
Ten Haaft, P
;
Verstrepen, B
;
Überla, K
;
Rosenwirth, B
;
Heeney, J
.
JOURNAL OF VIROLOGY,
1998, 72 (12)
:10281-10285

Ten Haaft, P
论文数: 0 引用数: 0
h-index: 0
机构: Biomed Primate Res Ctr, Dept Virol, NL-2280 GH Rijswijk, Netherlands

Verstrepen, B
论文数: 0 引用数: 0
h-index: 0
机构: Biomed Primate Res Ctr, Dept Virol, NL-2280 GH Rijswijk, Netherlands

Überla, K
论文数: 0 引用数: 0
h-index: 0
机构: Biomed Primate Res Ctr, Dept Virol, NL-2280 GH Rijswijk, Netherlands

Rosenwirth, B
论文数: 0 引用数: 0
h-index: 0
机构: Biomed Primate Res Ctr, Dept Virol, NL-2280 GH Rijswijk, Netherlands

Heeney, J
论文数: 0 引用数: 0
h-index: 0
机构: Biomed Primate Res Ctr, Dept Virol, NL-2280 GH Rijswijk, Netherlands
[60]
Kinetics of antiviral activity by human immunodeficiency virus type 1-specific cytotoxic T lymphocytes (CTL) and rapid selection of CTL escape virus in vitro
[J].
Van Baalen, CA
;
Schutten, M
;
Huisman, RC
;
Boers, PHM
;
Gruters, RA
;
Osterhaus, ADME
.
JOURNAL OF VIROLOGY,
1998, 72 (08)
:6851-6857

Van Baalen, CA
论文数: 0 引用数: 0
h-index: 0
机构: Erasmus Univ, Inst Virol, NL-3000 DR Rotterdam, Netherlands

Schutten, M
论文数: 0 引用数: 0
h-index: 0
机构: Erasmus Univ, Inst Virol, NL-3000 DR Rotterdam, Netherlands

Huisman, RC
论文数: 0 引用数: 0
h-index: 0
机构: Erasmus Univ, Inst Virol, NL-3000 DR Rotterdam, Netherlands

Boers, PHM
论文数: 0 引用数: 0
h-index: 0
机构: Erasmus Univ, Inst Virol, NL-3000 DR Rotterdam, Netherlands

Gruters, RA
论文数: 0 引用数: 0
h-index: 0
机构: Erasmus Univ, Inst Virol, NL-3000 DR Rotterdam, Netherlands

Osterhaus, ADME
论文数: 0 引用数: 0
h-index: 0
机构: Erasmus Univ, Inst Virol, NL-3000 DR Rotterdam, Netherlands