Synthesis of Two Bioactive Natural Products: FR252921 and Pseudotrienic Acid B

被引：31

作者：

Amans, Dominique ^{[1
]}

Bellosta, Veronique ^{[1
]}

Cossy, Janine ^{[1
]}

机构：

[1] ESPCI ParisTcch, CNRS, Chim Organ Lab, F-75231 Paris 05, France

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2009年 / 15卷 / 14期

关键词：

asymmetric catalysis; cross-coupling; metathesis; natural products; polyenes; TITANIUM-CARBOHYDRATE COMPLEXES; FLUORESCENS NO. 408813; ENANTIOSELECTIVE SYNTHESES; SELECTIVE SYNTHESIS; MIXED ANHYDRIDE; ALDOL-REACTION; EFFICIENT; CONSTRUCTION; ALKYNES; MACROLACTONIZATION;

D O I：

10.1002/chem.200802649

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Concise and highly convergent syntheses of the immunosuppressive agent FR252921 and the related antimicrobial natural product pseudotrienic acid B were achieved from a common intermediate by using optically active titanium complexes to control the configuration of the stereogenic centers, a highly stereo and regioselective cross-metathesis to generate the triene moieties, and a Stille cross-coupling to install the dienic units.

引用

页码：3457 / 3473

页数：17

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