Total synthesis of pseudotrienic acid B:: A bioactive metabolite from Pseudomonas sp MF 381-IODS

被引：12

作者：

Amans, Dominique ^{[1
]}

Bellosta, Veronique ^{[1
]}

Cossy, Janine ^{[1
]}

机构：

[1] ESPCI, Associe CNRS, Chim Organ Lab, F-75231 Paris 05, France

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 35期

关键词：

cross-coupling; crotyltitanation; metathesis; natural products; total synthesis;

D O I：

10.1002/anie.200601114

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Acid advancement: An efficient and highly convergent stereoselective synthesis of pseudotrienic acid B (see structure) has been achieved. Synthetic highlights include a crotyltitanation reaction to control the stereogenic centers at C11 and C20, a cross-metathesis reaction to synthesize the triene moiety, and a Stille cross-coupling reaction to complete the assembly of the carbon framework of the natural product. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：5870 / 5874

页数：5

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