Enantioselective Nitroaldol Reaction Catalyzed by Sterically Modified Salen-Chromium Complexes

被引：91

作者：

Kowalczyk, Rafal ^{[1
]}

Kwiatkowski, Piotr ^{[2
]}

Skarzewski, Jacek ^{[1
]}

Jurczak, Janusz ^{[2
,3
]}

机构：

[1] Wroclaw Univ Technol, Fac Chem, Dept Organ Chem, PL-50370 Wroclaw, Poland

[2] Polish Acad Sci, Inst Organ Chem, PL-01224 Warsaw, Poland

[3] Univ Warsaw, Dept Chem, PL-02093 Warsaw, Poland

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2009年 / 74卷 / 02期

关键词：

ASYMMETRIC HENRY REACTION; DIELS-ALDER REACTIONS; CHIRAL METALLOSALEN COMPLEXES; HALO ALDOL REACTION; (SALEN)CHROMIUM(III) COMPLEXES; (SALEN)CR(III) COMPLEXES; METAL(SALEN) COMPLEXES; RATIONAL DESIGN; BASE COMPLEX; ALDEHYDES;

D O I：

10.1021/jo802107b

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A group of modified (salen)Cr(III)Cl complexes with bulky benzylic substituents in the 3,3'-position of the salicylidene moiety have been successfully applied for the asymmetric nitroaldol reaction. The readily accessible complex bearing 3-phenylpent-3-yl groups (2 mol %) leads to beta-nitro alcohols ill Lip to 92% yield and 94% ee.

引用

页码：753 / 756

页数：4

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