Broadly neutralizing antibodies against influenza virus and prospects for universal therapies

被引：125

作者：

Ekiert, Damian C. ^{[1
]}

Wilson, Ian A. ^{[1
,2
]}

机构：

[1] Scripps Res Inst, Dept Mol Biol, La Jolla, CA 92037 USA

[2] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA

来源：

CURRENT OPINION IN VIROLOGY | 2012年 / 2卷 / 02期

关键词：

C VIRUS; MONOCLONAL-ANTIBODY; A VIRUS; HEMAGGLUTININ; EPITOPE; GLYCOPROTEIN; DESIGN; H2; H1; VACCINATION;

D O I：

10.1016/j.coviro.2012.02.005

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Vaccines are the gold standard for the control and prevention of infectious diseases, but a number of important human diseases remain challenging targets for vaccine development. An influenza vaccine that confers broad spectrum, long-term protection remains elusive. Several broadly neutralizing antibodies have been identified that protect against multiple subtypes of influenza A viruses, and crystal structures of several neutralizing antibodies in complex with the major influenza surface antigen, hemagglutinin, have revealed at least 3 highly conserved epitopes. Our understanding of the molecular details of these antibody-antigen interactions has suggested new strategies for the rational design of improved influenza vaccines, and has inspired the development of new antivirals for the treatment of influenza infections.

引用

页码：134 / 141

页数：8

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