Transient Flare of Ulcerative Colitis After Fecal Microbiota Transplantation for Recurrent Clostridium difficile Infection

被引：186

作者：

De Leon, Lauren M. ^{[1
]}

Watson, James B. ^{[1
]}

Kelly, Colleen R. ^{[1
]}

机构：

[1] Brown Univ, Rhode Isl Hosp, Alpert Sch Med, Providence, RI 02903 USA

来源：

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY | 2013年 / 11卷 / 08期

关键词：

Adverse Event; Risk; Side Effect; IBD; INFLAMMATORY-BOWEL-DISEASE; DIARRHEA; BACTERIOTHERAPY;

D O I：

10.1016/j.cgh.2013.04.045

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Clostridium difficile infection (CDI) is a common cause of infectious diarrhea and is usually treated with metronidazole or vancomycin. CDI recurs in 15%-30% of patients after the initial episode and in up to 65% after a second episode. Recurrent infections are a challenge to treat, and patients are usually managed with prolonged pulsed or tapered vancomycin. Fecal microbiota transplantation is an alternative treatment that has a 91% rate of success worldwide, with no reported complications. We describe a patient with ulcerative colitis that had been quiescent for more than 20 years who developed a flare of ulcerative colitis after fecal microbiota transplantation, indicating the need for caution in treating CDI with fecal microbiota transplantation in patients with inflammatory bowel disease.

引用

页码：1036 / 1038

页数：3

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