Identification of a novel HLA-Cw05 allele, Cw0503

被引：1

作者：

Huang, LQ ^{[1
]}

Boon, T ^{[1
]}

Van Pel, A ^{[1
]}

机构：

[1] Ludwig Inst Canc Res, Brussels Branch, B-1200 Brussels, Belgium

来源：

TISSUE ANTIGENS | 2000年 / 55卷 / 05期

关键词：

HLA-Cw*0503; cDNA cloning; nucleotide sequencing;

D O I：

10.1034/j.1399-0039.2000.550515.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

HLA-Cw*05 is one of the least polymorphic subgroups of HLA-C; so far only two alleles, namely Cw*0501 and Cw*0502, have been reported. We report here the identification of a third allele, Cw*0503, in a Caucasian individual. Cw*0503 is closely related to Cw*0501 with only six nucleotide substitutions clustering over a fragment of 48 nucleotides at the beginning of exon 4. All these six substitutions at the same positions have been found only in HLA-B*44 alleles, suggesting that Cw*0503 is a result of recombination between Cw*0501 and one of B*44 alleles.

引用

页码：473 / 474

页数：2

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Identification of a novel HLA-Cw*05 allele, Cw*0503

Identification of a novel HLA-Cw05 allele, Cw0503