On topography and functionality in the B-D rings of cephalostatin cytotoxins

被引：21

作者：

LaCour, TG ^{[1
]}

Guo, CX

Ma, SH

Jeong, JU

Boyd, MR

Matsunaga, S

Fusetani, N

Fuchs, PL

机构：

[1] Purdue Univ, Dept Chem, W Lafayette, IN 47907 USA

[2] NCI, Frederick Canc Res & Dev Ctr, Frederick, MD 21702 USA

[3] Univ Tokyo, Marine Biochem Lab, Bunkyo Ku, Tokyo 113, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 17期

关键词：

D O I：

10.1016/S0960-894X(99)00430-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Analogues 12'beta-hydroxycephalostatin 1 (9), 7'-deoxyritterazine G (10), and 14-epi-7'-deoxyritterazine B (11) were prepared via our protocol for unsymmetrical pyrazine synthesis. Cytotoxicity against human tumors was also determined for the first time for ritterazines, with femtomolar potency and a high correlation to cephalostatins observed. The SAR of these and related. compounds provide insight into the importance of topography and certain chemical functionality in the B-D and B'-D' rings of cephalostatin type antineoplastics. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：2587 / 2592

页数：6

共 24 条

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