TH2, allergy and group 2 innate lymphoid cells

被引:523
作者
Licona-Limon, Paula [1 ]
Kim, Lark Kyun [1 ,2 ]
Palm, Noah W. [1 ]
Flavell, Richard A. [1 ,2 ]
机构
[1] Yale Univ, Sch Med, Dept Immunobiol, New Haven, CT 06520 USA
[2] Yale Univ, Sch Med, Howard Hughes Med Inst, New Haven, CT 06510 USA
关键词
THYMIC STROMAL LYMPHOPOIETIN; TRANSCRIPTION FACTOR GATA3; T-CELLS; AIRWAY HYPERRESPONSIVENESS; ADAPTIVE IMMUNITY; DENDRITIC CELLS; MAST-CELLS; LUNG; CYTOKINE; INFLAMMATION;
D O I
10.1038/ni.2617
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The initiation of type 2 immune responses by the epithelial cell-derived cytokines IL-25, IL-33 and TSLP has been an area of extensive research in the past decade. Such studies have led to the identification of a new innate lymphoid subset that produces the canonical type 2 cytokines IL-5, IL-9 and IL-13 in response to IL-25 and IL-33. These group 2 or type 2 innate lymphoid cells (ILC2 cells) represent a critical source of type 2 cytokines in vivo and serve an important role in orchestrating the type 2 response to helminths and allergens. Further characterization of ILC2 cell biology will enhance the understanding of type 2 responses and may identify new treatments for asthma, allergies and parasitic infections. Interactions between ILC2 cells and the adaptive immune system, as well as examination of potential roles for ILC2 cells in the maintenance of homeostasis, promise to be particularly fruitful areas of future research.
引用
收藏
页码:536 / 542
页数:7
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