Cellular stress and signal transduction responses to human cytomegalovirus infection

被引：30

作者：

Evers, DL

Wang, X

Huang, ES

机构：

[1] Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA

[2] Univ N Carolina, Dept Microbiol & Immunol, Chapel Hill, NC 27599 USA

[3] Univ N Carolina, Dept Med, Chapel Hill, NC 27599 USA

[4] Univ N Carolina, Curriculum Genet & Mol Biol, Chapel Hill, NC 27599 USA

来源：

MICROBES AND INFECTION | 2004年 / 6卷 / 12期

关键词：

cytomegalovirus; signal transduction; cytokine; antiviral;

D O I：

10.1016/j.micinf.2004.05.026

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Human cytomegalovirus (HCMV) receptor-ligand interactions and viral entry excite cellular responses such as receptor tyrosine kinase and mitogen-activated protein kinase signaling, cytoskeletal rearrangement, and the induction of transcription factors, prostaglandins, and cytokines. Bi-phasic stimulation of these pathways, excepting interferon, facilitates productive viral infection and likely contributes to viral pathogenesis. (c) 2004 Elsevier SAS. All rights reserved.

引用

收藏

页码：1084 / 1093

页数：10

相关论文

共 84 条

[31] The role of MKK1/2 kinase activity in human cytomegalovirus infection [J].

Johnson, RA ;

Ma, XL ;

Yurochko, AD ;

Huang, ES .

JOURNAL OF GENERAL VIROLOGY, 2001, 82 :493-497

[32]

JONES NL, 1986, EUR J CELL BIOL, V41, P304

[33] Human cytomegalovirus IE1 protein activates AP-1 through a cellular protein kinase(s) [J].

Kim, S ;

Yu, SS ;

Lee, IS ;

Ohno, S ;

Yim, J ;

Kim, S ;

Kang, HS .

JOURNAL OF GENERAL VIROLOGY, 1999, 80 :961-969

[34] Synergistic activation of the human cytomegalovirus major immediate early promoter by prostaglandin E2 and cytokines [J].

Kline, JN ;

Hunninghake, GM ;

He, B ;

Monick, MM ;

Hunninghake, GW .

EXPERIMENTAL LUNG RESEARCH, 1998, 24 (01) :3-14

[35]

Kovacs A, 1996, AM J PATHOL, V149, P1531

[36] MULTIPLE MECHANISMS ARE IMPLICATED IN THE REGULATION OF NF-KAPPA-B ACTIVITY DURING HUMAN CYTOMEGALOVIRUS-INFECTION [J].

KOWALIK, TF ;

WING, B ;

HASKILL, JS ;

AZIZKHAN, JC ;

BALDWIN, AS ;

HUANG, ES .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (03) :1107-1111

[37] p53, the cellular gatekeeper for growth and division [J].

Levine, AJ .

CELL, 1997, 88 (03) :323-331

[38] INTERACTION OF THE 72-KILODALTON HUMAN CYTOMEGALOVIRUS IE1 GENE-PRODUCT WITH E2F1 COINCIDES WITH E2F-DEPENDENT ACTIVATION OF DIHYDROFOLATE-REDUCTASE TRANSCRIPTION [J].

MARGOLIS, MJ ;

PAJOVIC, S ;

WONG, EL ;

WADE, M ;

JUPP, R ;

NELSON, JA ;

AZIZKHAN, JC .

JOURNAL OF VIROLOGY, 1995, 69 (12) :7759-7767

[39] Inhibitors of human cytomegalovirus replication drastically reduce the activity of the viral protein kinase pUL97 [J].

Marschall, M ;

Stein-Gerlach, M ;

Freitag, M ;

Kupfer, R ;

van den Bogaard, M ;

Stamminger, T .

JOURNAL OF GENERAL VIROLOGY, 2001, 82 :1439-1450

[40]

Miller DM, 1999, J IMMUNOL, V162, P6107

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