A practical mild, one-pot, regiospecific synthesis of 2,3-disubstituted indoles via consecutive Sonogashira and Cacchi reactions

被引：129

作者：

Lu, Bruce Z. ^{[1
]}

Zhao, Wenyi ^{[1
]}

Wei, Han-Xun ^{[1
]}

Dufour, Marine ^{[1
]}

Farina, Vittorio ^{[1
]}

Senanayake, Chris H. ^{[1
]}

机构：

[1] Boehringer Ingelheim Pharmaceut Inc, Dept Chem Dev, Richmond, VA 23219 USA

来源：

ORGANIC LETTERS | 2006年 / 8卷 / 15期

关键词：

COPPER-FREE; COUPLING REACTION; TERMINAL ALKYNES; ARYL BROMIDES; PALLADIUM; EFFICIENT; VINYL; HALIDES; CYCLIZATION; 1-ALKYNES;

D O I：

10.1021/ol061136q

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A practical one-pot, regiospecific three-component process for the synthesis of 2,3-disubstituted indoles was developed via consecutive Pd-catalyzed Sonogashira coupling, amidopalladation, and reductive elimination.

引用

页码：3271 / 3274

页数：4

共 29 条

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