A general and efficient method for the formylation of aryl and heteroaryl bromides

被引：178

作者：

Klaus, S

Neumann, H

Zapf, A

Strübing, D

Hübner, S

Almena, J

Riemeier, T

Gross, P

Sarich, M

Krahnert, WR

Rossen, K

Beller, M

机构：

[1] Degussa AG, D-63457 Hanau, Germany

[2] Univ Rostock eV IfOK, Lab Inst Organ Katalyse, D-18059 Rostock, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 01期

关键词：

aldehydes; aryl halides; carbon monoxide; formylation; palladium;

D O I：

10.1002/anie.200502697

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) The key to the general and efficient palladium-catalyzed formylation of aryl and heteroaryl bromides is the use of the di-1-adamantyl-n-butylphosphane (cataC-Xium A) as ligand. Low pressure of the synthesis gas and appropriate choice of the base are also important for high yields (up to 99%) of a broad range of (hetero)aromatic aldehydes at unprecedented low catalyst concentrations (see scheme; TMEDA= N,N,N′,N′-tetramethylethylenediamine). © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：154 / 158

页数：5

共 61 条

[51] Double carbonylation of aryl iodides with diethylamine catalyzed by dinuclear palladium complexes [J].