Synthesis of Biologically Active Carbazole Alkaloids Using Selective Transition-metal-catalyzed Coupling Reactions

被引：218

作者：

Knoelker, Hans-Joachim ^{[1
]}

机构：

[1] Tech Univ Dresden, Dept Chem, D-01069 Dresden, Germany

来源：

CHEMISTRY LETTERS | 2009年 / 38卷 / 01期

关键词：

1ST TOTAL-SYNTHESIS; IRON-MEDIATED SYNTHESIS; ENANTIOSELECTIVE TOTAL-SYNTHESIS; TRICARBONYLIRON-DIENE COMPLEXES; ORGANIC-SYNTHESIS; OXIDATIVE CYCLIZATIONS; NEOCARAZOSTATIN-B; EPOCARBAZOLIN-B; CLAUSINE-L; CARQUINOSTATIN;

D O I：

10.1246/cl.2009.8

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Highly convergent syntheses of substituted carbazoles are most conveniently achieved using organometallic chemistry. Construction of the carbazole framework via the iron-mediated route proceeds by a sequence of C-C and C-N bond formation. In the highly efficient palladium-catalyzed route the C-N bond is formed first followed by generation of the C-C bond. This article highlights some recent developments and applications to the total synthesis of biologically active carbazole alkaloids.

引用

页码：8 / 13

页数：6

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