Observation of positive selection within hypervariable regions of a newly identified DNA virus (SEN virus)

被引：36

作者：

Umemura, T

Tanaka, Y

Kiyosawa, K

Alter, HJ

Shih, JWK ^{[1
]}

机构：

[1] NIH, Warren G Magnuson Clin Ctr, Dept Transfus Med, Bethesda, MD 20892 USA

[2] Shinshu Univ, Sch Med, Dept Internal Med 2, Matsumoto, Nagano 3908621, Japan

来源：

FEBS LETTERS | 2002年 / 510卷 / 03期

关键词：

evolutionary rate; hypervariable regions; phylogenetic analysis; positive selection; TT virus; Circoviridae;

D O I：

10.1016/S0014-5793(01)03258-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

To elucidate the evolution of SEN virus (SEN-V), serial sequences of chronically SEN-V-infected patients were analyzed. In the hypervariable regions, non-synonymous substitutions significantly predominated. This could be attributed to positive selection in evading immune surveillance of the hosts and to establish a persistent infection. On the basis of the sequences in the two open reading frames of SEN-V DNA, the rate of synonymous substitutions was 7.32X10(-4) per site per year. Since this rate is close to RNA viruses and higher than other DNA viruses, the SEN-V might be replicated by machinery with poor or no proofreading function. (C) 2002 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies.

引用

页码：171 / 174

页数：4

共 31 条

[1] A CONSTANT RATE OF SPONTANEOUS MUTATION IN DNA-BASED MICROBES [J].