Stereoselective synthesis of the pyrroloisoquinoline ring system

被引：43

作者：

Allin, SM ^{[1
]}

James, SL

Martin, WP

Smith, TAD

Elsegood, MRJ

机构：

[1] Loughborough Univ Technol, Dept Chem, Loughborough LE11 3TU, Leics, England

[2] GlaxoSmithKline Pharmaceut, Synthet Chem, Harlow CM19 5AW, Essex, England

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 2001年 / 22期

关键词：

D O I：

10.1039/b105402n

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In this paper we report a facile and stereoselective approach to the pyrroloisoquinoline ring system through the application of N-acyliminium chemistry from readily available non-racemic chiral templates. The stereochemical outcome of the cyclisation reactions has been determined by NOE and X-ray crystallography. We also demonstrate the synthetic potential of our new approach through removal of the pendant hydroxymethyl auxiliary from a product of cyclisation.

引用

页码：3029 / 3036

页数：8

共 25 条

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