MicroRNA-143 functions as a tumor suppressor in human esophageal squamous cell carcinoma

被引：77

作者：

Ni, Yang ^{[1
]}

Meng, Long ^{[1
]}

Wang, Liguang ^{[1
]}

Dong, Wei ^{[1
]}

Shen, Hongchang ^{[1
]}

Wang, Guanghui ^{[1
]}

Liu, Qi ^{[1
]}

Du, Jiajun ^{[1
]}

机构：

[1] Shandong Univ, Prov Hosp, Dept Thorac Surg, Jinan, Shandong, Peoples R China

来源：

GENE | 2013年 / 517卷 / 02期

关键词：

Esophageal cancer; microRNA-143; microRNA-145; ERK5; Tumor suppressor; COMPARATIVE GENOMIC HYBRIDIZATION; DOWN-REGULATION; PROMOTES APOPTOSIS; CERVICAL-CANCER; EXPRESSION; MIR-143; PROFILE; GENES; INVASION; AND-145;

D O I：

10.1016/j.gene.2012.12.031

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Esophageal cancer is one of the most common cancers worldwide with a poor prognosis. MicroRNAs(miRNAs) are a class of naturally occurring small noncoding RNAs and play an important role in cancer initiation and development. In this study, we demonstrate that the expression levels of miR-143 and miR-145 were significantly decreased in ESCC tissues in comparison with adjacent normal esophageal squamous tissues(NESTs). Furthermore, an inverse correlation between miR-143 and tumor invasion depth and lymph node metastasis was observed. The enforced expression of miR-143 induced growth suppression and apoptosis of ESCC cells. Rescue of miR-143 significantly suppressed the ESCC cells migration and invasion capabilities. Moreover, we show that functions of miR-143 in ESCC are mediated at least in part by the inhibition of extracellular signal regulated kinase-5(ERK-5) activity. These results prove that miR-143 may act as a tumor suppressor in ESCC (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：197 / 204

页数：8

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