Disruption of metabolic pathways - Perspectives for the treatment of cancer

被引：12

作者：

Araujo, EP ^{[1
]}

Carvalheira, JB ^{[1
]}

Velloso, LA ^{[1
]}

机构：

[1] Univ Estadual Campinas, FCM, DCM, Dept Internal Med, BR-13084970 Campinas, SP, Brazil

来源：

CURRENT CANCER DRUG TARGETS | 2006年 / 6卷 / 01期

关键词：

D O I：

10.2174/156800906775471734

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Several growth-promoting signaling pathways have tight molecular connections with metabolic-related signal transduction systems. By controlling these pathways, cancer cells gain autonomy over energy-acquiring systems and, thus, expand their potential for proliferation. Here, we discuss the use of drug and antisense oligonucleotide approaches to inhibit metabolic pathways in cancer cells and their potential use in the therapeutics of cancer.

引用

页码：77 / 87

页数：11

共 136 条

[31]

DEL PL, 1997, SCIENCE, V278, P687

[32] Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase [J].

Delcommenne, M ;

Tan, C ;

Gray, V ;

Rue, L ;

Woodgett, J ;

Dedhar, S .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (19) :11211-11216

[33] Directed antisense therapy confirms the role of protein kinase C-α in the tumorigenicity of pancreatic cancer [J].

Denham, DW ;

Franz, MG ;

Denham, W ;

Zervos, EE ;

Gower, WR ;

Rosemurgy, AS ;

Norman, J .

SURGERY, 1998, 124 (02) :218-223

[34] How BAD phosphorylation is good for survival [J].

Downward, J .

NATURE CELL BIOLOGY, 1999, 1 (02) :E33-E35

[35] CREB is a regulatory target for the protein kinase Akt/PKB [J].

Du, KY ;

Montminy, M .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (49) :32377-32379

[36] Regulation of neuronal survival by the serine-threonine protein kinase Akt [J].

Dudek, H ;

Datta, SR ;

Franke, TF ;

Birnbaum, MJ ;

Yao, RJ ;

Cooper, GM ;

Segal, RA ;

Kaplan, DR ;

Greenberg, ME .

SCIENCE, 1997, 275 (5300) :661-665

[37]

FEI ZL, 1995, MOL CELL BIOL, V15, P4232

[38] Identification of a PKB/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinase [J].

Feng, JH ;

Park, J ;

Cron, P ;

Hess, D ;

Hemmings, BA .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (39) :41189-41196

[39] Antisense therapeutics: lessons from early clinical trials [J].

Flaherty, KT ;

Stevenson, JP ;

O'Dwyer, PJ .

CURRENT OPINION IN ONCOLOGY, 2001, 13 (06) :499-505

[40] THE PROTEIN-KINASE ENCODED BY THE AKT PROTOONCOGENE IS A TARGET OF THE PDGF-ACTIVATED PHOSPHATIDYLINOSITOL 3-KINASE [J].

FRANKE, TF ;

YANG, SI ;

CHAN, TO ;

DATTA, K ;

KAZLAUSKAS, A ;

MORRISON, DK ;

KAPLAN, DR ;

TSICHLIS, PN .

CELL, 1995, 81 (05) :727-736

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