Copper-mediated asymmetric transformations

被引：4

作者：

Alexakis, A ^{[1
]}

机构：

[1] Univ Geneva, Dept Organ Chem, CH-1211 Geneva, Switzerland

来源：

PURE AND APPLIED CHEMISTRY | 2002年 / 74卷 / 01期

关键词：

D O I：

10.1351/pac200274010037

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Copper-catalyzed reactions include the enantioselective conjugate addition and the S(N)2' substitution. We describe the genesis of these reactions, the choice of the primary organometallic reagent, and our studies on finding new Michael acceptors and new ligands. We also report on the use of the zinc enolate generated upon conjugate addition.

引用

页码：37 / 42

页数：6

共 27 条

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[2] 2-D
[3] Alexakis A, 2001, SYNLETT, P927
[4] Asymmetric conjugate addition to alkylidene malonates
Alexakis, A
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[J]. TETRAHEDRON-ASYMMETRY, 2001, 12 (08) : 1151 - 1157
[5] Alexakis A, 2001, SYNLETT, P1375
[6] Tandem enantioselective conjugate addition: Electrophile trapping reactions. application in the formation of syn or anti aldols
Alexakis, A
Trevitt, GP
Bernardinelli, G
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2001, 123 (18) : 4358 - 4359
[7] Alexakis A, 1999, SYNLETT, P1811
[8] Acceleration of the conjugate addition of diethyl zinc to enones by either Cu(OTf)(2) or trivalent phosphorus ligands
Alexakis, A
Vastra, J
Mangeney, P
[J]. TETRAHEDRON LETTERS, 1997, 38 (44) : 7745 - 7748
[9] Asymmetric conjugate addition of diethyl zinc to enones with tartrate chiral phosphite ligands
Alexakis, A
Vastra, J
Burton, J
Mangeney, P
[J]. TETRAHEDRON-ASYMMETRY, 1997, 8 (19) : 3193 - 3196
[10] Asymmetric conjugate addition of diethyl zinc to enones with chiral phosphorus ligands derived from TADDOL
Alexakis, A
Vastra, J
Burton, J
Benhaim, C
Mangeney, P
[J]. TETRAHEDRON LETTERS, 1998, 39 (43) : 7869 - 7872

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