New efficient construction of the ABC core of the taxoids via a sequence of consecutive cobalt(I)-mediated [2+2+2] and [4+2] cyclizations

被引：43

作者：

Petit, M ^{[1
]}

Chouraqui, G ^{[1
]}

Phansavath, P ^{[1
]}

Aubert, C ^{[1
]}

Malacria, M ^{[1
]}

机构：

[1] Univ Paris 06, Lab Chim Organ Synth Associe, CNRS, F-75252 Paris 05, France

来源：

ORGANIC LETTERS | 2002年 / 4卷 / 06期

关键词：

D O I：

10.1021/ol025623r

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] A new and efficient sequence of two consecutive cyclizations, a cobalt(I)-mediated [2 + 2 + 2] cyclotrimerization and a Diels-Alder reaction, is proposed to allow the formation of the ABC core of the taxoids in 65% overall yield, starting from an acyclic polyunsaturated precursor.

引用

收藏

页码：1027 / 1029

页数：3

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