Promoter proximal pausing on genes in metazoans

被引：79

作者：

Gilmour, David S. ^{[1
]}

机构：

[1] Penn State Univ, Dept Biochem & Mol Biol, Ctr Gene Regulat, University Pk, PA 16802 USA

来源：

CHROMOSOMA | 2009年 / 118卷 / 01期

关键词：

RNA-POLYMERASE-II; TRANSCRIPTIONAL ACTIVATION DOMAINS; NEGATIVE ELONGATION-FACTOR; HEPATITIS-DELTA ANTIGEN; CLEAVAGE FACTOR TFIIS; HEAT-SHOCK; IN-VIVO; P-TEFB; HSP70; PROMOTER; GAGA FACTOR;

D O I：

10.1007/s00412-008-0182-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The past two decades of research into transcriptional control of protein-encoding genes in eukaryotes have focused on regulatory mechanisms that act by controlling the recruitment of Pol II to a gene's promoter. Recent genome-wide analyses of the distribution of Pol II indicates that Pol II is concentrated in the promoter regions of thousands of genes in human and Drosophila cells. In many cases, Pol II may have initiated transcription but paused in the promoter proximal region. Hence, release of Pol II from the promoter region into the body of a gene is now recognized as a common rate-limiting step in the control of gene expression. Notably, most genes with paused Pol II are expressed indicating that the pause can be transient. What causes Pol II to concentrate in the promoter region and how it is released to transcribe a gene are the focus of this review.

引用

页码：1 / 10

页数：10

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