Etiopathogenesis of inflammatory bowel disease: The importance of the pediatric perspective

被引：56

作者：

Oliva-Hemker, M

Fiocchi, C

机构：

[1] Johns Hopkins Univ Hosp, Div Pediat Gastroenterol & Nutr, Sch Med, Dept Pediat, Baltimore, MD 21287 USA

[2] Case Western Reserve Univ, Sch Med, Dept Med, Div Gastroenterol, Cleveland, OH USA

来源：

INFLAMMATORY BOWEL DISEASES | 2002年 / 8卷 / 02期

关键词：

inflammatory bowel disease; Crohn's disease; ulcerative colitis; etiopathogenesis; children;

D O I：

10.1097/00054725-200203000-00008

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Inflammatory bowel disease (IBD) is now recognized as a common chronic disease affecting children and adolescents. This article will review recent advances made in the fields of genetics, epidemiology, gut ecology, and immunology regarding the etiopathogenesis of IBD, with particular emphasis on the contributions made by pediatric studies. Areas where further study of the pediatric age group would be beneficial will be highlighted.

引用

页码：112 / 128

页数：17

共 176 条

[11]

BILLER JA, 1999, J PEDIAT GASTROENTER, V21, P224

[12] Enhanced leukocyte binding by intestinal microvascular endothelial cells in inflammatory bowel disease [J].

Binion, DG ;

West, GA ;

Ina, K ;

Ziats, NP ;

Emancipator, SN ;

Fiocchi, C .

GASTROENTEROLOGY, 1997, 112 (06) :1895-1907

[13] Animal models of mucosal inflammation and their relation to human inflammatory bowel disease [J].

Blumberg, RS ;

Saubermann, LJ ;

Strober, W .

CURRENT OPINION IN IMMUNOLOGY, 1999, 11 (06) :648-656

[14] TUMOR-NECROSIS-FACTOR-ALPHA IN STOOL AS A MARKER OF INTESTINAL INFLAMMATION [J].

BRAEGGER, CP ;

NICHOLLS, S ;

MURCH, SH ;

STEPHENS, S ;

MACDONALD, TT .

LANCET, 1992, 339 (8785) :89-91

[15] TUMOR-NECROSIS-FACTOR ALPHA-PRODUCING CELLS IN THE INTESTINAL-MUCOSA OF CHILDREN WITH INFLAMMATORY BOWEL-DISEASE [J].

BREESE, EJ ;

MICHIE, CA ;

NICHOLLS, SW ;

MURCH, SH ;

WILLIAMS, CB ;

DOMIZIO, P ;

WALKERSMITH, JA ;

MACDONALD, TT .

GASTROENTEROLOGY, 1994, 106 (06) :1455-1466

[16] AUTOANTIBODIES IN HUMAN ULCERATIVE COLITIS [J].

BROBERGER, O ;

PERLMANN, P .

JOURNAL OF EXPERIMENTAL MEDICINE, 1959, 110 (05) :657-674

[17] Elevation of serum interleukin-6 but not serum-soluble interleukin-2 receptor in children with Crohn's disease [J].

Bross, DA ;

Leichtner, AM ;

Zurakowski, D ;

Law, T ;

Bousvaros, A .

JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 1996, 23 (02) :164-171

[18] TRENDS IN INCIDENCE RATES OF ULCERATIVE-COLITIS AND CROHNS-DISEASE [J].

CALKINS, BM ;

LILIENFELD, AM ;

GARLAND, CF ;

MENDELOFF, AI .

DIGESTIVE DISEASES AND SCIENCES, 1984, 29 (10) :913-920

[19] A META-ANALYSIS OF THE ROLE OF SMOKING IN INFLAMMATORY BOWEL-DISEASE [J].

CALKINS, BM .

DIGESTIVE DISEASES AND SCIENCES, 1989, 34 (12) :1841-1854

[20] UPPER AND LOWER GASTROINTESTINAL ENDOSCOPY IN CHILDREN AND ADOLESCENTS WITH CROHNS-DISEASE - A PROSPECTIVE-STUDY [J].

CAMERON, DJS .

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 1991, 6 (04) :355-358

← 1 2 3 4 5 6 7 8 9 10 →