Antineoplastic agents .340. Isolation and structural elucidation of bryostatins 16-18

被引：50

作者：

Pettit, GR ^{[1
]}

Gao, F ^{[1
]}

Blumberg, PM ^{[1
]}

Herald, CL ^{[1
]}

Coll, JC ^{[1
]}

Kamano, Y ^{[1
]}

Lewin, NE ^{[1
]}

Schmidt, JM ^{[1
]}

Chapuis, JC ^{[1
]}

机构：

[1] ARIZONA STATE UNIV, DEPT CHEM, TEMPE, AZ 85287 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 1996年 / 59卷 / 03期

关键词：

D O I：

10.1021/np960100b

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Separation of two trace cancer cell growth inhibitory (P388 leukemia) fractions from about 1000 kg of wet Gulf of Mexico Bugula neritina (Bryozoa) has led to the isolation of bryostatins 16-18 (2-4). A combination of HRFABMS and high-field (400 MHz) H-1- and C-13-NMR spectral analyses were employed to assign the structures. The three new 20-desoxybryostatins 16 (2), 17 (3), and 18 (4) showed significant growth inhibitory activity (P388 ED(50), 2, 9.3 x 10(-3) mu g/ mL, 3, 1.9 x 10(-2) mu g/mL, and 4, 3.3 x 10(-3) mu g/mL) against murine P388 lymphotytic leukemia.

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页码：286 / 289

页数：4

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