beta catenin;
protein interaction mapping;
protein processing;
post-translational;
TCF transcription factors;
Wnt proteins;
D O I:
10.1038/emm.2006.1
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
The Wnt signaling pathway is conserved in various species from worms to mammals, and plays important roles in cellular proliferation, differentiation, and migration. Wnt stabilizes cytoplasmic beta-catenin and then the accumulated beta-catenin is translocated into the nucleus, where it activates the transcriptional factor T-cell factor (Tcf)/lymphoid enhancer factor (Lef), and thereby stimulates the expression of genes including c-myc, c-jun, fra-1, and cyclin D1. Tight regulation of this response involves post-translational modifications of the components of the Wnt signaling pathway. Phosphorylation, ubiquitination, and sumoylation have been shown to affect the half-life of beta-catenin and the transcriptional activity of Tcf/Lef. The precise spatio-temporal patterns of these multiple modifications determine the driving force of various cellular responses.
机构:Univ Washington, Sch Med, Howard Hughes Med Inst, Dept Pharmacol,Ctr Dev Biol, Seattle, WA 98195 USA
Veeman, MT
;
Axelrod, JD
论文数: 0引用数: 0
h-index: 0
机构:Univ Washington, Sch Med, Howard Hughes Med Inst, Dept Pharmacol,Ctr Dev Biol, Seattle, WA 98195 USA
Axelrod, JD
;
Moon, RT
论文数: 0引用数: 0
h-index: 0
机构:
Univ Washington, Sch Med, Howard Hughes Med Inst, Dept Pharmacol,Ctr Dev Biol, Seattle, WA 98195 USAUniv Washington, Sch Med, Howard Hughes Med Inst, Dept Pharmacol,Ctr Dev Biol, Seattle, WA 98195 USA
机构:Univ Washington, Sch Med, Howard Hughes Med Inst, Dept Pharmacol,Ctr Dev Biol, Seattle, WA 98195 USA
Veeman, MT
;
Axelrod, JD
论文数: 0引用数: 0
h-index: 0
机构:Univ Washington, Sch Med, Howard Hughes Med Inst, Dept Pharmacol,Ctr Dev Biol, Seattle, WA 98195 USA
Axelrod, JD
;
Moon, RT
论文数: 0引用数: 0
h-index: 0
机构:
Univ Washington, Sch Med, Howard Hughes Med Inst, Dept Pharmacol,Ctr Dev Biol, Seattle, WA 98195 USAUniv Washington, Sch Med, Howard Hughes Med Inst, Dept Pharmacol,Ctr Dev Biol, Seattle, WA 98195 USA