An efficient and versatile synthesis of acylpolyamine spider toxins

被引：15

作者：

Nihei, K

Kato, MJ

Yamane, T

Palma, MS

Konno, K ^{[1
]}

机构：

[1] Sao Paulo State Univ, Inst Biosci Rio Claro, Dept Biol, Ctr Study Social Insects, BR-13506900 Rio Claro, SP, Brazil

[2] Univ Sao Paulo, Inst Chem, BR-05508900 Sao Paulo, Brazil

[3] Inst Butantan, Mol Toxicol Lab, BR-05503900 Sao Paulo, SP, Brazil

[4] FAPESP, CEPID, Ctr Appl Toxinol, BR-05468901 Sao Paulo, SP, Brazil

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 03期

基金：

巴西圣保罗研究基金会;

关键词：

D O I：

10.1016/S0960-894X(01)00733-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

An efficient and versatile synthesis of acylpolyamine spider toxins was developed based on the structural classification of the Nephila and Nephilengys spider toxins using the 2-nitrobenzenesulfonamide protecting group. The naturally occurring toxins 1-5 representing each structural type have been efficiently synthesized by this method in a high overall yield with few steps. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：299 / 302

页数：4

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