MicroRNAs in atherosclerosis

被引：50

作者：

Chen, Ku-Chung ^{[1
,2
]}

Juo, Suh-Hang Hank ^{[1
,2
]}

机构：

[1] Kaohsiung Med Univ Hosp, Dept Med Res, Kaohsiung, Taiwan

[2] Kaohsiung Med Univ, Dept Med Genet, Kaohsiung 807, Taiwan

来源：

KAOHSIUNG JOURNAL OF MEDICAL SCIENCES | 2012年 / 28卷 / 12期

关键词：

Atherosclerosis; Cardiovascular disease; MicroRNA; SMOOTH-MUSCLE-CELLS; CORONARY-ARTERY-DISEASE; NEOINTIMAL LESION FORMATION; GROWTH-FACTOR-BETA; ENDOTHELIAL DYSFUNCTION; INFLAMMATORY RESPONSE; IN-VITRO; CARDIOVASCULAR-DISEASE; SIGNALING PATHWAYS; VASCULAR-DISEASE;

D O I：

10.1016/j.kjms.2012.04.001

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

MicroRNAs are endogenously expressed small noncoding RNAs that regulate gene expression at the post-transcriptional level. MicroRNAs have emerged as key regulators of several physiological and pathophysiological processes in the cardiovascular system. Aberrant expression of microRNAs has been implicated in the pathophysiological processes underlying the development of atherosclerosis and cardiovascular disease, including change in endothelial function, vascular smooth muscle cell proliferation and migration, macrophage function, and foam cell formation. In this review, we summarize the recent data showing the roles of microRNAs in cell studies, studies on atherosclerotic mice, and human studies. Copyright (c) 2012, Elsevier Taiwan LLC. All rights reserved.

引用

页码：631 / 640

页数：10

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