MicroRNA as a New Player in the Cell Cycle

被引：41

作者：

Chen, Dongliang ^{[1
]}

Farwell, Mary A. ^{[1
]}

Zhang, Baohong ^{[1
]}

机构：

[1] E Carolina Univ, Dept Biol, Greenville, NC 27858 USA

来源：

JOURNAL OF CELLULAR PHYSIOLOGY | 2010年 / 225卷 / 02期

关键词：

EMBRYONIC STEM-CELLS; TUMOR-SUPPRESSOR; DNA METHYLATION; BREAST-CANCER; N-MYC; EXPRESSION; GENE; P27(KIP1); RNA; DIFFERENTIATION;

D O I：

10.1002/jcp.22234

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

MicroRNAs (miRNAs) are a newly identified class of small regulatory non-coding endogenous RNAs that are ubiquitous from animals to plants and have pivotal functions in nearly all biological and metabolic processes. Increasing evidence shows that miRNAs are also new players regulating many protein-coding genes and specific pathways during the cell cycle. This review focuses on the functions of miRNAs in the cell cycle of differentiated cells and embryonic stem (ES) cells. Aberrant expression of these cell-cycle-related miRNAs may result in carcinogenesis, revealing the potential of miRNAs as therapeutic targets for clinical purposes. J. Cell. Physiol. 225: 296-301, 2010. (C) 2010 Wiley-Liss, Inc.

引用

页码：296 / 301

页数：6

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