Mono and bis double ester prodrugs of novel aminomethyl-THF 1 beta-methylcarbapenems

被引：6

作者：

Lin, YI

Bitha, P

Li, Z

Sakya, SM

Strohmeyer, TW

Lang, SA

Yang, YJ

Bhachech, N

Weiss, WJ

Petersen, PJ

Jacobus, NV

Bush, K

Testa, RT

机构：

[1] Wyeth-Ayerst Research, Div. of Amer. Home Prod. Corporation, Infectious Diseases Research Section, Pearl River

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 14期

关键词：

D O I：

10.1016/S0960-894X(97)00305-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Mono and bis double ester prodrugs of aminomethyl THF 1 beta-methylcarbapenems 1 were Mono double ester derivatives (2, 4 and 7) did not demonstrate significantly improved oral activity due to the presence of the charged species. However, bis double ester derivatives (3 and 5) demonstrated enhanced oral activity. (C) 1997 Elsevier Science Ltd.

引用

页码：1811 / 1816

页数：6

共 9 条

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Lin, YI
Bitha, P
Sakya, SM
Li, Z
Lang, SA
Yang, YJ
Bhachech, N
Weiss, WJ
Petersen, PJ
Jacobus, NV
Bush, K
Testa, RT
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[5] Synthesis and structure-activity relationships of novel THF 1 beta-methylcarbapenems
Lin, YI
Bitha, P
Sakya, SM
Strohmeyer, TW
Li, Z
Lee, VJ
Lang, SA
Yang, YJ
Bhachech, N
Weiss, WJ
Petersen, PJ
Jacobus, NV
Bush, K
Testa, RT
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[7] LIN YI, 1994, 34 INT C ANT AG CHEM
[8] WEISS WJ, 1994, 34 ICAACORL
[9] WEISS WJ, 1994, 34 ICAAC ORL

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