DNA binding by the Methanothermobacter thermautotrophicus Cdc6 protein is inhibited by the minichromosome maintenance helicase

被引：16

作者：

Kasiviswanathan, Rajesh ^{[1
]}

Shin, Jae-Ho ^{[1
]}

Kelman, Zvi ^{[1
]}

机构：

[1] Univ Maryland, Biotechnol Inst, Ctr Adv Res Biotechnol, Rockville, MD 20850 USA

来源：

JOURNAL OF BACTERIOLOGY | 2006年 / 188卷 / 12期

关键词：

D O I：

10.1128/JB.00168-06

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The Cdc6 proteins from the archaeon Methanothermobacter thermautotrophicus were previously shown to bind double-stranded DNA. It is shown here that the proteins also bind single-stranded DNA. Using minichromosome maintenance (MCM) helicase mutant proteins unable to bind DNA, it was found that the interaction of MCM with Cdc6 inhibits the DNA binding activity of Cdc6.

引用

页码：4577 / 4580

页数：4

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